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- Publisher Website: 10.3171/jns.1992.76.4.0679
- Scopus: eid_2-s2.0-0026534607
- PMID: 1545262
- WOS: WOS:A1992HK82600017
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Article: Laser-induced fluorescence: Experimental intraoperative delineation of tumor resection margins
Title | Laser-induced fluorescence: Experimental intraoperative delineation of tumor resection margins |
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Authors | |
Keywords | fluorescence detection glioma photoradiation therapy phthalocyanine rat tumor resection |
Issue Date | 1992 |
Citation | Journal of Neurosurgery, 1992, v. 76, n. 4, p. 679-686 How to Cite? |
Abstract | The ability of laser-induced fluorescence spectroscopy to delineate tumor margins intraoperatively was studied using a rat intracerebral glioma model. A fluorescent dye, chloro-aluminum phthalocyanine tetrasulfonate (ClAlPcS4), was injected intravenously 24 hours before tumor resection. The animals underwent tumor resection under the operating microscope, guided by laser- induced fluorescence measurement in one group (Group 1) and visual assessment in the other (Group 2). The Group 1 rats had a significantly reduced volume of residual tumor following resection (0.5 ± 0.2 cu mm vs. 13.7 ± 4.0 cu mm, mean ± standard error of the mean, p < 0.02). Three of the nine animals in Group 1 were tumor-free at 2 weeks following resection, compared with none of the 10 rats in Group 2 (p < 0.05). Interference from brain autofluorescence was minimized using spectrally resolved detection and the ClAlPcS4 dye, which has a 680-nm fluorescence peak significantly higher than the 470-nm autofluorescence peak of normal brain. Contrast ratios of up to 40:1 were found for glioma:normal brain fluorescence signals. Spatially- resolved spectra were acquired in approximately 5 seconds using a fiberoptic probe. This study demonstrates the ability of an intraoperative laser-induced fluorescence system to detect tumor margins that could not be identified with the operating microscope. |
Persistent Identifier | http://hdl.handle.net/10722/324977 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.173 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Poon, W. S. | - |
dc.contributor.author | Schomacker, K. T. | - |
dc.contributor.author | Deutsch, T. F. | - |
dc.contributor.author | Martuza, R. L. | - |
dc.date.accessioned | 2023-02-27T07:28:42Z | - |
dc.date.available | 2023-02-27T07:28:42Z | - |
dc.date.issued | 1992 | - |
dc.identifier.citation | Journal of Neurosurgery, 1992, v. 76, n. 4, p. 679-686 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | http://hdl.handle.net/10722/324977 | - |
dc.description.abstract | The ability of laser-induced fluorescence spectroscopy to delineate tumor margins intraoperatively was studied using a rat intracerebral glioma model. A fluorescent dye, chloro-aluminum phthalocyanine tetrasulfonate (ClAlPcS4), was injected intravenously 24 hours before tumor resection. The animals underwent tumor resection under the operating microscope, guided by laser- induced fluorescence measurement in one group (Group 1) and visual assessment in the other (Group 2). The Group 1 rats had a significantly reduced volume of residual tumor following resection (0.5 ± 0.2 cu mm vs. 13.7 ± 4.0 cu mm, mean ± standard error of the mean, p < 0.02). Three of the nine animals in Group 1 were tumor-free at 2 weeks following resection, compared with none of the 10 rats in Group 2 (p < 0.05). Interference from brain autofluorescence was minimized using spectrally resolved detection and the ClAlPcS4 dye, which has a 680-nm fluorescence peak significantly higher than the 470-nm autofluorescence peak of normal brain. Contrast ratios of up to 40:1 were found for glioma:normal brain fluorescence signals. Spatially- resolved spectra were acquired in approximately 5 seconds using a fiberoptic probe. This study demonstrates the ability of an intraoperative laser-induced fluorescence system to detect tumor margins that could not be identified with the operating microscope. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Neurosurgery | - |
dc.subject | fluorescence detection | - |
dc.subject | glioma | - |
dc.subject | photoradiation therapy | - |
dc.subject | phthalocyanine | - |
dc.subject | rat | - |
dc.subject | tumor resection | - |
dc.title | Laser-induced fluorescence: Experimental intraoperative delineation of tumor resection margins | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.3171/jns.1992.76.4.0679 | - |
dc.identifier.pmid | 1545262 | - |
dc.identifier.scopus | eid_2-s2.0-0026534607 | - |
dc.identifier.volume | 76 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 679 | - |
dc.identifier.epage | 686 | - |
dc.identifier.isi | WOS:A1992HK82600017 | - |