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- PMID: 33339152
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Article: Physicochemical characteristics of arginine enriched NaF varnish: an in vitro study
Title | Physicochemical characteristics of arginine enriched NaF varnish: an in vitro study |
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Authors | |
Keywords | arginine caries fluorides prevention varnish |
Issue Date | 2020 |
Publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/polymers |
Citation | Polymers, 2020, v. 12 n. 12, p. article no. 2998 How to Cite? |
Abstract | The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release. Six experimental formulations were prepared with L-arginine (L-Arg) and L-arginine monohydrochloride at 2%, 4%, and 8% w/v in a 5% NaF varnish, which served as a control. The varnishes were subjected to assessments for adhesion, viscosity, and NaF extraction. Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg |
Persistent Identifier | http://hdl.handle.net/10722/304644 |
ISSN | 2021 Impact Factor: 4.967 2020 SCImago Journal Rankings: 0.770 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | BIJLE, MN | - |
dc.contributor.author | Ekambaram, M | - |
dc.contributor.author | Lo, E | - |
dc.contributor.author | Yiu, C | - |
dc.date.accessioned | 2021-10-05T02:33:06Z | - |
dc.date.available | 2021-10-05T02:33:06Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Polymers, 2020, v. 12 n. 12, p. article no. 2998 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304644 | - |
dc.description.abstract | The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release. Six experimental formulations were prepared with L-arginine (L-Arg) and L-arginine monohydrochloride at 2%, 4%, and 8% w/v in a 5% NaF varnish, which served as a control. The varnishes were subjected to assessments for adhesion, viscosity, and NaF extraction. Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations. The Arg/F varnish release profiles were determined in polyacrylic lactate buffer (pH-4.5; 7 days) and artificial saliva (pH-7; 1 h, 24 h, and 12 weeks). Incorporation of L-Arg in NaF varnish significantly influences physical properties ameliorating retention (p < 0.001). L-Arg in NaF varnish institutes the Arg-F complex. Molecular dynamics suggests that NaF>Arg concentration denotes the stabilized environment compared to NaF<Arg (p < 0.001). The 2% Arg-NaF exhibits periodic perennial Arg/F release and shows significantly higher integrated mean F release than NaF (p < 0.001). Incorporating 2% L-arginine in 5% NaF varnish improves its physical properties and renders a stable matrix with enduring higher F/Arg release than control. | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/polymers | - |
dc.relation.ispartof | Polymers | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | arginine | - |
dc.subject | caries | - |
dc.subject | fluorides | - |
dc.subject | prevention | - |
dc.subject | varnish | - |
dc.title | Physicochemical characteristics of arginine enriched NaF varnish: an in vitro study | - |
dc.type | Article | - |
dc.identifier.email | Lo, E: edward-lo@hku.hk | - |
dc.identifier.email | Yiu, C: ckyyiu@hkucc.hku.hk | - |
dc.identifier.authority | Lo, E=rp00015 | - |
dc.identifier.authority | Yiu, C=rp00018 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/polym12122998 | - |
dc.identifier.pmid | 33339152 | - |
dc.identifier.pmcid | PMC7765578 | - |
dc.identifier.scopus | eid_2-s2.0-85098445117 | - |
dc.identifier.hkuros | 326250 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | article no. 2998 | - |
dc.identifier.epage | article no. 2998 | - |
dc.identifier.isi | WOS:000603111500001 | - |
dc.publisher.place | Switzerland | - |