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Conference Paper: Interferon-mediated AIM2 Inflammasome Dysfunction In Systemic Lupus Erythematosus
Title | Interferon-mediated AIM2 Inflammasome Dysfunction In Systemic Lupus Erythematosus |
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Authors | |
Issue Date | 2019 |
Publisher | Wiley for European Federation of Immunological Societies (EFIS). The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4141 |
Citation | The 17th International Congress of Immunology (IUIS 2019), Beijing, China, 19-23 October 2019. In European Journal of Immunology, 2019, v. 49 n. S3, p. 773, abstract no. O150 How to Cite? |
Abstract | Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder attributed by dysregulation
in both innate and adaptive immune responses. Type I interferon (IFN) is considered as the central
pathogenic cytokine in driving SLE development through its pleiotropic effects on various leukocytes
including monocytes. In a study comparing the transcriptome profiles of monocytes exposed to sera
from healthy subjects and SLE patients, genes of the NOD-like receptor signaling pathways, including
the DNA-binding molecule, AIM2, were significantly enriched. The role of AIM2 in SLE is not
completely clear and here we evaluated its function as a cytosolic autoantigen senor in activating the
inflammasome activity to produce active IL-1β and IL-18 via the proteolytic activity of caspase-1.
Compared with healthy individuals, monocytes from SLE patients exhibited higher expression of AIM2
and other inflammasome components caspase-1 and ASC; and concordantly produced higher levels
of IL-1β and IL-18 upon stimulation with dsDNA. AIM2 expression in SLE monocytes also positively
correlated with the expression of IFN-sensitive genes (ISGs) MX-1, IFIT-1 and LY6E. Healthy
monocytes cultured in SLE serum induced higher AIM2 transcript expression and in positive
correlation with ISGs induction. Furthermore, IFNα treatment induced expression of AIM2 mRNA
together with increased inflammasome-induced IL-18 and IL-1β secretion in a dose-dependent
manner. These findings suggest that dysregulated IFN-mediated AIM2 inflammasome activity may
play a role in SLE pathogenesis. The molecular mechanism by which IFN mediates AIM2 induction is
currently under investigation. |
Description | This conference is organized by the International Union of Immunological Societies (IUIS) and hosted by the Chinese Society for Immunology (CSI) |
Persistent Identifier | http://hdl.handle.net/10722/293889 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
DC Field | Value | Language |
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dc.contributor.author | Chow, JX | - |
dc.contributor.author | Lau, WCS | - |
dc.contributor.author | Chan, VSF | - |
dc.date.accessioned | 2020-11-23T08:23:18Z | - |
dc.date.available | 2020-11-23T08:23:18Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The 17th International Congress of Immunology (IUIS 2019), Beijing, China, 19-23 October 2019. In European Journal of Immunology, 2019, v. 49 n. S3, p. 773, abstract no. O150 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293889 | - |
dc.description | This conference is organized by the International Union of Immunological Societies (IUIS) and hosted by the Chinese Society for Immunology (CSI) | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder attributed by dysregulation in both innate and adaptive immune responses. Type I interferon (IFN) is considered as the central pathogenic cytokine in driving SLE development through its pleiotropic effects on various leukocytes including monocytes. In a study comparing the transcriptome profiles of monocytes exposed to sera from healthy subjects and SLE patients, genes of the NOD-like receptor signaling pathways, including the DNA-binding molecule, AIM2, were significantly enriched. The role of AIM2 in SLE is not completely clear and here we evaluated its function as a cytosolic autoantigen senor in activating the inflammasome activity to produce active IL-1β and IL-18 via the proteolytic activity of caspase-1. Compared with healthy individuals, monocytes from SLE patients exhibited higher expression of AIM2 and other inflammasome components caspase-1 and ASC; and concordantly produced higher levels of IL-1β and IL-18 upon stimulation with dsDNA. AIM2 expression in SLE monocytes also positively correlated with the expression of IFN-sensitive genes (ISGs) MX-1, IFIT-1 and LY6E. Healthy monocytes cultured in SLE serum induced higher AIM2 transcript expression and in positive correlation with ISGs induction. Furthermore, IFNα treatment induced expression of AIM2 mRNA together with increased inflammasome-induced IL-18 and IL-1β secretion in a dose-dependent manner. These findings suggest that dysregulated IFN-mediated AIM2 inflammasome activity may play a role in SLE pathogenesis. The molecular mechanism by which IFN mediates AIM2 induction is currently under investigation. | - |
dc.language | eng | - |
dc.publisher | Wiley for European Federation of Immunological Societies (EFIS). The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4141 | - |
dc.relation.ispartof | European Journal of Immunology | - |
dc.relation.ispartof | 17th International Congress of Immunology (IUIS 2019) | - |
dc.title | Interferon-mediated AIM2 Inflammasome Dysfunction In Systemic Lupus Erythematosus | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lau, WCS: cslau@hku.hk | - |
dc.identifier.email | Chan, VSF: sfvchan@hku.hk | - |
dc.identifier.authority | Lau, WCS=rp01348 | - |
dc.identifier.authority | Chan, VSF=rp01459 | - |
dc.description.nature | abstract | - |
dc.identifier.hkuros | 319040 | - |
dc.identifier.volume | 49 | - |
dc.identifier.issue | S3 | - |
dc.identifier.spage | 773, abstract no. O150 | - |
dc.identifier.epage | 773, abstract no. O150 | - |
dc.publisher.place | Germany | - |
dc.identifier.partofdoi | 10.1002/eji.201970400 | - |
dc.identifier.issnl | 0014-2980 | - |