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- Publisher Website: 10.1016/j.neurobiolaging.2020.09.025
- Scopus: eid_2-s2.0-85094891908
- PMID: 33139072
- WOS: WOS:000620649200016
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Article: Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study
Title | Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study |
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Authors | |
Keywords | Herpes simplex virus Cognition Alzheimer's disease Mendelian randomization |
Issue Date | 2021 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging |
Citation | Neurobiology of Aging, 2021, v. 99, p. 101.e11-101.e13 How to Cite? |
Abstract | This study assessed if any herpes simplex virus (HSV) infection was a genetically valid target for late-onset Alzheimer’s disease (AD) using 2-sample Mendelian randomization. We applied strong (p-value <5×10−6) and independent (r2 < 0.05) genetic variants for any HSV infection (n = 450,581) to genome wide association studies of cognitive function (n = 300,486), and late-onset AD (n = 455,258) to obtain estimates. Genetically predicted log odds of any HSV infection was not associated with cognitive function (mean difference 0.0004 per any HSV infection, 95% confidence interval (CI) −0.001 to 0.001), or late-onset AD (odds ratio (OR) 0.999, 95% CI 0.998–1.001). Different genetic variant selections produced similar results. Any HSV infection does not appear to be a genetically valid target of intervention in late-onset AD, suggesting a rethink of the relevance of any HSV infection to late-onset AD. |
Persistent Identifier | http://hdl.handle.net/10722/293736 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.488 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kwok, MK | - |
dc.contributor.author | Schooling, CM | - |
dc.date.accessioned | 2020-11-23T08:21:05Z | - |
dc.date.available | 2020-11-23T08:21:05Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Neurobiology of Aging, 2021, v. 99, p. 101.e11-101.e13 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293736 | - |
dc.description.abstract | This study assessed if any herpes simplex virus (HSV) infection was a genetically valid target for late-onset Alzheimer’s disease (AD) using 2-sample Mendelian randomization. We applied strong (p-value <5×10−6) and independent (r2 < 0.05) genetic variants for any HSV infection (n = 450,581) to genome wide association studies of cognitive function (n = 300,486), and late-onset AD (n = 455,258) to obtain estimates. Genetically predicted log odds of any HSV infection was not associated with cognitive function (mean difference 0.0004 per any HSV infection, 95% confidence interval (CI) −0.001 to 0.001), or late-onset AD (odds ratio (OR) 0.999, 95% CI 0.998–1.001). Different genetic variant selections produced similar results. Any HSV infection does not appear to be a genetically valid target of intervention in late-onset AD, suggesting a rethink of the relevance of any HSV infection to late-onset AD. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging | - |
dc.relation.ispartof | Neurobiology of Aging | - |
dc.subject | Herpes simplex virus | - |
dc.subject | Cognition | - |
dc.subject | Alzheimer's disease | - |
dc.subject | Mendelian randomization | - |
dc.title | Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study | - |
dc.type | Article | - |
dc.identifier.email | Kwok, MK: maggiek@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.authority | Kwok, MK=rp02051 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2020.09.025 | - |
dc.identifier.pmid | 33139072 | - |
dc.identifier.scopus | eid_2-s2.0-85094891908 | - |
dc.identifier.hkuros | 319541 | - |
dc.identifier.volume | 99 | - |
dc.identifier.spage | 101.e11 | - |
dc.identifier.epage | 101.e13 | - |
dc.identifier.isi | WOS:000620649200016 | - |
dc.publisher.place | United States | - |