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Article: Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes

TitleLgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes
Authors
KeywordsLgr5
Col22a1
Gdf5
synovial joint
joint development
Issue Date2019
PublisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com
Citation
Stem Cell Reports, 2019, v. 13 n. 4, p. 713-729 How to Cite?
AbstractThe synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor cells. However, lineage specification and progression toward the different tissues of the joint are not well understood. Here, by lineage-tracing studies we identify a population of Lgr5+ interzone cells that contribute to the formation of cruciate ligaments, synovial membrane, and articular chondrocytes of the joint. This finding is supported by single-cell transcriptome analyses. We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5+ cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes. Lgr5+ cells contribute to the repair of a joint defect with the re-establishment of a Col22a1-expressing superficial layer.
Persistent Identifierhttp://hdl.handle.net/10722/277434
ISSN
2017 Impact Factor: 6.537
2015 SCImago Journal Rankings: 5.523
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, F-
dc.contributor.authorChan, WCW-
dc.contributor.authorLam, Y-
dc.contributor.authorWang, X-
dc.contributor.authorChen, P-
dc.contributor.authorNiu, B-
dc.contributor.authorNg, VCW-
dc.contributor.authorYeo, JC-
dc.contributor.authorStricker, S-
dc.contributor.authorCheah, KSE-
dc.contributor.authorKoch, M-
dc.contributor.authorMundlos, S-
dc.contributor.authorNg, HH-
dc.contributor.authorChan, D-
dc.date.accessioned2019-09-20T08:50:59Z-
dc.date.available2019-09-20T08:50:59Z-
dc.date.issued2019-
dc.identifier.citationStem Cell Reports, 2019, v. 13 n. 4, p. 713-729-
dc.identifier.issn2213-6711-
dc.identifier.urihttp://hdl.handle.net/10722/277434-
dc.description.abstractThe synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor cells. However, lineage specification and progression toward the different tissues of the joint are not well understood. Here, by lineage-tracing studies we identify a population of Lgr5+ interzone cells that contribute to the formation of cruciate ligaments, synovial membrane, and articular chondrocytes of the joint. This finding is supported by single-cell transcriptome analyses. We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5+ cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes. Lgr5+ cells contribute to the repair of a joint defect with the re-establishment of a Col22a1-expressing superficial layer.-
dc.languageeng-
dc.publisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com-
dc.relation.ispartofStem Cell Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectLgr5-
dc.subjectCol22a1-
dc.subjectGdf5-
dc.subjectsynovial joint-
dc.subjectjoint development-
dc.titleLgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes-
dc.typeArticle-
dc.identifier.emailChan, WCW: cwilson@hku.hk-
dc.identifier.emailChen, P: pkchen@hku.hk-
dc.identifier.emailNiu, B: csniuben@hku.hk-
dc.identifier.emailNg, VCW: vcwng@hkucc.hku.hk-
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hk-
dc.identifier.emailChan, D: chand@hku.hk-
dc.identifier.authorityCheah, KSE=rp00342-
dc.identifier.authorityChan, D=rp00540-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.stemcr.2019.08.006-
dc.identifier.pmid31522976-
dc.identifier.scopuseid_2-s2.0-85071175145-
dc.identifier.hkuros306014-
dc.identifier.volume13-
dc.identifier.issue4-
dc.identifier.spage713-
dc.identifier.epage729-
dc.identifier.isiWOS:000489322400011-
dc.publisher.placeUnited States-

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