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Conference Paper: Liver cancer - genetics, cell signalling, and cancer stem cells and their translational implications
Title | Liver cancer - genetics, cell signalling, and cancer stem cells and their translational implications |
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Authors | |
Issue Date | 2017 |
Publisher | Division of Surgical Oncology, National Cancer Centre Singapore. |
Citation | Cancer and Stem Cell Biology (CSCB) Seminar Series, Duke-NUS Medical School, Singapore, 26 October 2017 How to Cite? |
Abstract | We investigated the mutational landscape of mTOR signaling cascade in hepatocellular carcinoma (HCC). W detected frequent mutations of TSC1/2 genes in HCCs, which likely disrupt the functions in suppressing the downstream mTOR activity and lead to aggressive tumor behavior. There are therapeutic benefits of the hyper-sensitivity towards Rapamycin. TSC1/2 mutations may define a molecular subset of HCC with potential significance of specific drug therapy. In addition, cancer stem cells (CSCs) are capable of selfrenewal, maintaining tumor propagation, metastasis and chemo-resistance. In HCC, we have identified CD24 and CD47, among others, as novel liver CSC markers. HCC cells positive for these markers are more chemoresistant than marker-negative cells. They are functional markers that drive hepatocarcinogenesis through specific signaling pathways. Our work using antibodies targeting these markers has shown promising data in animal models. Furthermore, tumor microenvironment plays an important role in regulating cancer cells. The potential interaction of liver CSCs and tumor microenvironment as exemplified by cancer-associated fibroblasts will be presented. |
Persistent Identifier | http://hdl.handle.net/10722/269318 |
DC Field | Value | Language |
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dc.contributor.author | Ng, IOL | - |
dc.date.accessioned | 2019-04-23T10:04:45Z | - |
dc.date.available | 2019-04-23T10:04:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Cancer and Stem Cell Biology (CSCB) Seminar Series, Duke-NUS Medical School, Singapore, 26 October 2017 | - |
dc.identifier.uri | http://hdl.handle.net/10722/269318 | - |
dc.description.abstract | We investigated the mutational landscape of mTOR signaling cascade in hepatocellular carcinoma (HCC). W detected frequent mutations of TSC1/2 genes in HCCs, which likely disrupt the functions in suppressing the downstream mTOR activity and lead to aggressive tumor behavior. There are therapeutic benefits of the hyper-sensitivity towards Rapamycin. TSC1/2 mutations may define a molecular subset of HCC with potential significance of specific drug therapy. In addition, cancer stem cells (CSCs) are capable of selfrenewal, maintaining tumor propagation, metastasis and chemo-resistance. In HCC, we have identified CD24 and CD47, among others, as novel liver CSC markers. HCC cells positive for these markers are more chemoresistant than marker-negative cells. They are functional markers that drive hepatocarcinogenesis through specific signaling pathways. Our work using antibodies targeting these markers has shown promising data in animal models. Furthermore, tumor microenvironment plays an important role in regulating cancer cells. The potential interaction of liver CSCs and tumor microenvironment as exemplified by cancer-associated fibroblasts will be presented. | - |
dc.language | eng | - |
dc.publisher | Division of Surgical Oncology, National Cancer Centre Singapore. | - |
dc.relation.ispartof | Duke-NUS Medical School, Singapore | - |
dc.title | Liver cancer - genetics, cell signalling, and cancer stem cells and their translational implications | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Ng, IOL: iolng@hku.hk | - |
dc.identifier.authority | Ng, IOL=rp00335 | - |
dc.identifier.hkuros | 286487 | - |
dc.publisher.place | Singapore | - |