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- Publisher Website: 10.1073/pnas.1607179113
- Scopus: eid_2-s2.0-84975799342
- PMID: 27274054
- WOS: WOS:000378272400053
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Article: GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis
Title | GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis |
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Authors | |
Keywords | Guanine nucleotide exchange factors Rac GTPases Neurite growth |
Issue Date | 2016 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2016, v. 113, n. 25, p. 6973-6978 How to Cite? |
Abstract | © 2016, National Academy of Sciences. All rights reserved. Although previous studies have identified many extracellular guidance molecules and intracellular signaling proteins that regulate axonal outgrowth and extension, most were conducted in the context of unidirectional neurite growth, in which the guidance cues either attract or repel growth cones. Very few studies addressed how intracellular signaling molecules differentially specify bidirectional outgrowth. Here, using the bipolar PLM neurons in Caenorhabditis elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio and TIAM-1 promote anterior and posterior neurite extension, respectively. The Rac subfamily GTPases act downstream of the GEFs; CED-10/Rac1 is activated by TIAM-1, whereas CED-10 and MIG-2/RhoG act redundantly downstream of UNC-73. Moreover, these two pathways antagonize each other and thus regulate the directional bias of neuritogenesis. Our study suggests that directional specificity of neurite extension is conferred through the intracellular activation of distinct GEFs and Rac GTPases. |
Persistent Identifier | http://hdl.handle.net/10722/265694 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Chaogu | - |
dc.contributor.author | Diaz-Cuadros, Margarete | - |
dc.contributor.author | Chalfie, Martin | - |
dc.date.accessioned | 2018-12-03T01:21:25Z | - |
dc.date.available | 2018-12-03T01:21:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2016, v. 113, n. 25, p. 6973-6978 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265694 | - |
dc.description.abstract | © 2016, National Academy of Sciences. All rights reserved. Although previous studies have identified many extracellular guidance molecules and intracellular signaling proteins that regulate axonal outgrowth and extension, most were conducted in the context of unidirectional neurite growth, in which the guidance cues either attract or repel growth cones. Very few studies addressed how intracellular signaling molecules differentially specify bidirectional outgrowth. Here, using the bipolar PLM neurons in Caenorhabditis elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio and TIAM-1 promote anterior and posterior neurite extension, respectively. The Rac subfamily GTPases act downstream of the GEFs; CED-10/Rac1 is activated by TIAM-1, whereas CED-10 and MIG-2/RhoG act redundantly downstream of UNC-73. Moreover, these two pathways antagonize each other and thus regulate the directional bias of neuritogenesis. Our study suggests that directional specificity of neurite extension is conferred through the intracellular activation of distinct GEFs and Rac GTPases. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject | Guanine nucleotide exchange factors | - |
dc.subject | Rac GTPases | - |
dc.subject | Neurite growth | - |
dc.title | GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.1607179113 | - |
dc.identifier.pmid | 27274054 | - |
dc.identifier.scopus | eid_2-s2.0-84975799342 | - |
dc.identifier.volume | 113 | - |
dc.identifier.issue | 25 | - |
dc.identifier.spage | 6973 | - |
dc.identifier.epage | 6978 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.isi | WOS:000378272400053 | - |
dc.identifier.issnl | 0027-8424 | - |