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- Publisher Website: 10.1016/j.neuron.2015.09.049
- Scopus: eid_2-s2.0-84945570462
- PMID: 26539892
- WOS: WOS:000365765400012
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Article: Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans
Title | Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans |
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Authors | |
Issue Date | 2015 |
Citation | Neuron, 2015, v. 88, n. 3, p. 514-527 How to Cite? |
Abstract | © 2015 Elsevier Inc. Although Hox genes specify the differentiation of neuronal subtypes along the anterior-posterior axis, their mode of action is not entirely understood. Using two subtypes of the touch receptor neurons (TRNs) in C. elegans, we found that a "posterior induction" mechanism underlies the Hox control of terminal neuronal differentiation. The anterior subtype maintains a default TRN state, whereas the posterior subtype undergoes further morphological and transcriptional specification induced by the posterior Hox proteins, mainly EGL-5/Abd-B. Misexpression of the posterior Hox proteins transformed the anterior TRN subtype toward a posterior identity both morphologically and genetically. The specification of the posterior subtype requires EGL-5-induced repression of TALE cofactors, which antagonize EGL-5 functions, and the activation of rfip-1, a component of recycling endosomes, which mediates Hox activities by promoting subtype-specific neurite outgrowth. Finally, EGL-5 is required for subtype-specific circuit formation by acting in both the sensory neuron and downstream interneuron to promote functional connectivity. |
Persistent Identifier | http://hdl.handle.net/10722/265677 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 7.728 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Chaogu | - |
dc.contributor.author | Diaz-Cuadros, Margarete | - |
dc.contributor.author | Chalfie, Martin | - |
dc.date.accessioned | 2018-12-03T01:21:21Z | - |
dc.date.available | 2018-12-03T01:21:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Neuron, 2015, v. 88, n. 3, p. 514-527 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265677 | - |
dc.description.abstract | © 2015 Elsevier Inc. Although Hox genes specify the differentiation of neuronal subtypes along the anterior-posterior axis, their mode of action is not entirely understood. Using two subtypes of the touch receptor neurons (TRNs) in C. elegans, we found that a "posterior induction" mechanism underlies the Hox control of terminal neuronal differentiation. The anterior subtype maintains a default TRN state, whereas the posterior subtype undergoes further morphological and transcriptional specification induced by the posterior Hox proteins, mainly EGL-5/Abd-B. Misexpression of the posterior Hox proteins transformed the anterior TRN subtype toward a posterior identity both morphologically and genetically. The specification of the posterior subtype requires EGL-5-induced repression of TALE cofactors, which antagonize EGL-5 functions, and the activation of rfip-1, a component of recycling endosomes, which mediates Hox activities by promoting subtype-specific neurite outgrowth. Finally, EGL-5 is required for subtype-specific circuit formation by acting in both the sensory neuron and downstream interneuron to promote functional connectivity. | - |
dc.language | eng | - |
dc.relation.ispartof | Neuron | - |
dc.title | Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.neuron.2015.09.049 | - |
dc.identifier.pmid | 26539892 | - |
dc.identifier.scopus | eid_2-s2.0-84945570462 | - |
dc.identifier.volume | 88 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 514 | - |
dc.identifier.epage | 527 | - |
dc.identifier.eissn | 1097-4199 | - |
dc.identifier.isi | WOS:000365765400012 | - |
dc.identifier.issnl | 0896-6273 | - |