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- Publisher Website: 10.1016/j.semcdb.2014.04.003
- Scopus: eid_2-s2.0-84901289279
- PMID: 24718321
- WOS: WOS:000337873100008
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Article: Cancer mouse models: Past, present and future
| Title | Cancer mouse models: Past, present and future |
|---|---|
| Authors | |
| Keywords | PDX Cas9 Cancer models Transgenics Gene targeting |
| Issue Date | 2014 |
| Citation | Seminars in Cell and Developmental Biology, 2014, v. 27, p. 54-60 How to Cite? |
| Abstract | The development and advances in gene targeting technology over the past three decades has facilitated the generation of cancer mouse models that recapitulate features of human malignancies. These models have been and still remain instrumental in revealing the complexities of human cancer biology. However, they will need to evolve in the post-genomic era of cancer research. In this review we will highlight some of the key developments over the past decades and will discuss the new possibilities of cancer mouse models in the light of emerging powerful gene manipulating tools. © 2014. |
| Persistent Identifier | http://hdl.handle.net/10722/249096 |
| ISSN | 2023 Impact Factor: 6.2 2023 SCImago Journal Rankings: 2.612 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Khaled, Walid T. | - |
| dc.contributor.author | Liu, Pentao | - |
| dc.date.accessioned | 2017-10-27T05:59:05Z | - |
| dc.date.available | 2017-10-27T05:59:05Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.citation | Seminars in Cell and Developmental Biology, 2014, v. 27, p. 54-60 | - |
| dc.identifier.issn | 1084-9521 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/249096 | - |
| dc.description.abstract | The development and advances in gene targeting technology over the past three decades has facilitated the generation of cancer mouse models that recapitulate features of human malignancies. These models have been and still remain instrumental in revealing the complexities of human cancer biology. However, they will need to evolve in the post-genomic era of cancer research. In this review we will highlight some of the key developments over the past decades and will discuss the new possibilities of cancer mouse models in the light of emerging powerful gene manipulating tools. © 2014. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Seminars in Cell and Developmental Biology | - |
| dc.subject | PDX | - |
| dc.subject | Cas9 | - |
| dc.subject | Cancer models | - |
| dc.subject | Transgenics | - |
| dc.subject | Gene targeting | - |
| dc.title | Cancer mouse models: Past, present and future | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1016/j.semcdb.2014.04.003 | - |
| dc.identifier.pmid | 24718321 | - |
| dc.identifier.scopus | eid_2-s2.0-84901289279 | - |
| dc.identifier.volume | 27 | - |
| dc.identifier.spage | 54 | - |
| dc.identifier.epage | 60 | - |
| dc.identifier.eissn | 1096-3634 | - |
| dc.identifier.isi | WOS:000337873100008 | - |
| dc.identifier.issnl | 1084-9521 | - |