File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Total synthesis of fumagillol
| Title | Total synthesis of fumagillol |
|---|---|
| Authors | |
| Issue Date | 2010 |
| Publisher | American Chemical Society. |
| Citation | The 239th American Chemical Society National Meeting, San Francisco, CA, 21-25 March 2010 How to Cite? |
| Abstract | Inhibitors of
angiogenesis are expected to be of great clinical potential in the treatment of
many diseases including solid tumors, diabetic retinopathy, rheumatoid
arthritis, psoriasis and obesity.1 Recent clinical studies showed
that when given in combination with chemotherapies, some antiangiogenic agents
produced much better responses in cancer treatment.2 Among
antiangiogenic agents, fumagillin and related naturally occurring or
semisynthetic analogues (1-4) have received significant attention.3 Herein we
describe a concise total syntheses of (±)-fumagillol in 15 steps with an
overall yield of 16% from abundant and simple starting materials, using our
recently developed Lewis acid promoted catalytic carbonyl ene cyclization4
as a key step.
References
1. Folkman, J. Nat. Med. 1995, 1, 27.
2. Jain, R. K. Science 2005, 307, 58 and references therein.
3. Bernier, S. G.; Lazarus, D. D.; Clark, E.; Doyle, B.; Labenski, M. T.; Thompson, C. D.; Westlin, W. F.; Hannig G. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 10768.
4. (a) Yang, D.; Yang, M.; Zhu,N.-Y. Org. Lett. 2003, 5, 3749. (b) Li, C., Ph.D.thesis, The University of Hong Kong (2008). |
| Persistent Identifier | http://hdl.handle.net/10722/224414 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, X | - |
| dc.contributor.author | Yang, D | - |
| dc.date.accessioned | 2016-04-05T02:03:58Z | - |
| dc.date.available | 2016-04-05T02:03:58Z | - |
| dc.date.issued | 2010 | - |
| dc.identifier.citation | The 239th American Chemical Society National Meeting, San Francisco, CA, 21-25 March 2010 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/224414 | - |
| dc.description.abstract | Inhibitors of angiogenesis are expected to be of great clinical potential in the treatment of many diseases including solid tumors, diabetic retinopathy, rheumatoid arthritis, psoriasis and obesity.1 Recent clinical studies showed that when given in combination with chemotherapies, some antiangiogenic agents produced much better responses in cancer treatment.2 Among antiangiogenic agents, fumagillin and related naturally occurring or semisynthetic analogues (1-4) have received significant attention.3 Herein we describe a concise total syntheses of (±)-fumagillol in 15 steps with an overall yield of 16% from abundant and simple starting materials, using our recently developed Lewis acid promoted catalytic carbonyl ene cyclization4 as a key step. References 1. Folkman, J. Nat. Med. 1995, 1, 27. 2. Jain, R. K. Science 2005, 307, 58 and references therein. 3. Bernier, S. G.; Lazarus, D. D.; Clark, E.; Doyle, B.; Labenski, M. T.; Thompson, C. D.; Westlin, W. F.; Hannig G. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 10768. 4. (a) Yang, D.; Yang, M.; Zhu,N.-Y. Org. Lett. 2003, 5, 3749. (b) Li, C., Ph.D.thesis, The University of Hong Kong (2008). | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society. | - |
| dc.relation.ispartof | The American Chemical Society National Meeting | - |
| dc.title | Total synthesis of fumagillol | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Yang, D: yangdan@hku.hk | - |
| dc.identifier.authority | Yang, D=rp00825 | - |
| dc.identifier.hkuros | 181052 | - |
| dc.publisher.place | San Francisco, CA | - |