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- Publisher Website: 10.2174/9781608054534113010005
- Scopus: eid_2-s2.0-84882619007
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Book Chapter: Genetics of Menopause and Menopausal Age
Title | Genetics of Menopause and Menopausal Age |
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Authors | |
Keywords | Age at natural menopause Genetic factors Genome-wide association Candidate genes Microarrays |
Issue Date | 2013 |
Publisher | Bentham Science Publishers |
Citation | Genetics of Menopause and Menopausal Age. In Dvornyk, V (Ed.), Current Topics in Menopause, p. 20-53. Sharjah, United Arab Emirates; Oak Park, Ill.: Bentham Science Publishers, 2013 How to Cite? |
Abstract | Menopause marks an upper limit of a female’s reproductive period. It is one of the key physiological events in female life and has a pronounced effect on postmenopausal health. Age at natural menopause (ANM) has been associated with many health problems and therefore attracted much attention in the last two decades. As a complex trait, ANM is determined by many genetic and environmental factors and their interactions. During last two decades, large efforts have been made to determine a genetic basis of natural menopause and its timing, which allowed for identifying a number of candidate genes and genomic regions. However, the problem is still far from its solution. The systems approach, which incorporates candidate gene association studies, genome-wide association studies, linkage analysis, gene expression microarrays and proteomics in a single pipeline, may open new venues and greatly advance progress in this area. |
Persistent Identifier | http://hdl.handle.net/10722/180360 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Dvornyk, V | en_US |
dc.date.accessioned | 2013-01-21T01:40:37Z | - |
dc.date.available | 2013-01-21T01:40:37Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Genetics of Menopause and Menopausal Age. In Dvornyk, V (Ed.), Current Topics in Menopause, p. 20-53. Sharjah, United Arab Emirates; Oak Park, Ill.: Bentham Science Publishers, 2013 | en_US |
dc.identifier.isbn | 9781608055159 | - |
dc.identifier.uri | http://hdl.handle.net/10722/180360 | - |
dc.description.abstract | Menopause marks an upper limit of a female’s reproductive period. It is one of the key physiological events in female life and has a pronounced effect on postmenopausal health. Age at natural menopause (ANM) has been associated with many health problems and therefore attracted much attention in the last two decades. As a complex trait, ANM is determined by many genetic and environmental factors and their interactions. During last two decades, large efforts have been made to determine a genetic basis of natural menopause and its timing, which allowed for identifying a number of candidate genes and genomic regions. However, the problem is still far from its solution. The systems approach, which incorporates candidate gene association studies, genome-wide association studies, linkage analysis, gene expression microarrays and proteomics in a single pipeline, may open new venues and greatly advance progress in this area. | - |
dc.language | eng | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.relation.ispartof | Current Topics in Menopause | en_US |
dc.subject | Age at natural menopause | - |
dc.subject | Genetic factors | - |
dc.subject | Genome-wide association | - |
dc.subject | Candidate genes | - |
dc.subject | Microarrays | - |
dc.title | Genetics of Menopause and Menopausal Age | en_US |
dc.type | Book_Chapter | en_US |
dc.identifier.email | Dvornyk, V: dvornyk@hku.hk | en_US |
dc.identifier.authority | Dvornyk, V=rp00693 | en_US |
dc.identifier.doi | 10.2174/9781608054534113010005 | - |
dc.identifier.scopus | eid_2-s2.0-84882619007 | - |
dc.identifier.hkuros | 213005 | en_US |
dc.identifier.spage | 20 | en_US |
dc.identifier.epage | 53 | en_US |
dc.publisher.place | Sharjah, United Arab Emirates; Oak Park, Ill. | - |