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Article: Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin

TitleEffect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin
Authors
Wan, JMGrimble, RF
Issue Date1987
PublisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/
Citation
Clinical Science, 1987, v. 72 n. 3, p. 383-385 How to Cite?
DOI: http://dx.doi.org/10.1042/cs0720383
AbstractDietary fat influences many aspects of immune function. Escherichia coli endotoxin is a potent stimulator of interleukin 1 production from macrophages. The present study examines the effect of feeding with fat diets rich (corn oil) and poor (coconut oil) in linoleate at high and low concentrations on responses to endotoxin. Spleen phosphatidylcholine linoleate contents were higher in the corn oil than in the coconut oil group and arachidonate concentrations were highest in the group fed a high concentration of corn oil. Coconut oil completely abolished the responses to endotoxin. The inhibitory effects of coconut oil could largely be due to reduced prostaglandin and leukotriene synthesis.
Persistent Identifierhttp://hdl.handle.net/10722/178455
ISSN
0143-5221
2023 Impact Factor: 6.7
2023 SCImago Journal Rankings: 1.565
ISI Accession Number ID
WOS:A1987G007200017

 

DC FieldValueLanguage
dc.contributor.authorWan, JMen_US
dc.contributor.authorGrimble, RFen_US
dc.date.accessioned2012-12-19T09:47:47Z-
dc.date.available2012-12-19T09:47:47Z-
dc.date.issued1987en_US
dc.identifier.citationClinical Science, 1987, v. 72 n. 3, p. 383-385en_US
dc.identifier.issn0143-5221en_US
dc.identifier.urihttp://hdl.handle.net/10722/178455-
dc.description.abstractDietary fat influences many aspects of immune function. Escherichia coli endotoxin is a potent stimulator of interleukin 1 production from macrophages. The present study examines the effect of feeding with fat diets rich (corn oil) and poor (coconut oil) in linoleate at high and low concentrations on responses to endotoxin. Spleen phosphatidylcholine linoleate contents were higher in the corn oil than in the coconut oil group and arachidonate concentrations were highest in the group fed a high concentration of corn oil. Coconut oil completely abolished the responses to endotoxin. The inhibitory effects of coconut oil could largely be due to reduced prostaglandin and leukotriene synthesis.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/en_US
dc.relation.ispartofClinical Scienceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCocosen_US
dc.subject.meshCorn Oil - Pharmacologyen_US
dc.subject.meshDietary Fats - Pharmacologyen_US
dc.subject.meshEndotoxins - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshEscherichia Colien_US
dc.subject.meshFemaleen_US
dc.subject.meshInterleukin-1 - Biosynthesisen_US
dc.subject.meshLinoleic Aciden_US
dc.subject.meshLinoleic Acids - Administration & Dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleEffect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxinen_US
dc.typeArticleen_US
dc.identifier.emailWan, JM: jmfwan@hku.hken_US
dc.identifier.authorityWan, JM=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1042/cs0720383-
dc.identifier.pmid3545648-
dc.identifier.scopuseid_2-s2.0-0023106283en_US
dc.identifier.volume72en_US
dc.identifier.issue3en_US
dc.identifier.spage383en_US
dc.identifier.epage385en_US
dc.identifier.isiWOS:A1987G007200017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWan, JM=8930305000en_US
dc.identifier.scopusauthoridGrimble, RF=7006833714en_US
dc.identifier.issnl0143-5221-

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