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Article: A potential mechanism of action of colloidal bismuth subcitrate: Diffusion barrier to hydrochloric acid

TitleA potential mechanism of action of colloidal bismuth subcitrate: Diffusion barrier to hydrochloric acid
Authors
Lee, SP
Issue Date1982
Citation
Scandinavian Journal Of Gastroenterology, Supplement, 1982, v. 17 n. 80, p. 17-21 How to Cite?
AbstractThe mode of action of colloidal bismuth subcitrate (CBS), a colloidal bismuth preparation often used in the treatment of gastroduodenal ulcers, is unknown. The precipitation characteristics of CBS were determined by titration with hydrochloric acid and gastric juice. The precipitation pH were 4.0 and 3.5 respectively. Preoperative administration of CBS resulted in a preferential accumulation of bismuth in chronic gastric ulcers as determined by tissue bismuth assays. CBS and gastric glycoprotein formed an in vitro complex which markedly retarded the migration of H+. One of the mechanisms by which CBS promotes ulcer healing is through its behaviour as a diffusion barrier to hydrochloric acid.
Persistent Identifierhttp://hdl.handle.net/10722/175626
ISSN
0085-5928

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:00:11Z-
dc.date.available2012-11-26T09:00:11Z-
dc.date.issued1982en_US
dc.identifier.citationScandinavian Journal Of Gastroenterology, Supplement, 1982, v. 17 n. 80, p. 17-21en_US
dc.identifier.issn0085-5928en_US
dc.identifier.urihttp://hdl.handle.net/10722/175626-
dc.description.abstractThe mode of action of colloidal bismuth subcitrate (CBS), a colloidal bismuth preparation often used in the treatment of gastroduodenal ulcers, is unknown. The precipitation characteristics of CBS were determined by titration with hydrochloric acid and gastric juice. The precipitation pH were 4.0 and 3.5 respectively. Preoperative administration of CBS resulted in a preferential accumulation of bismuth in chronic gastric ulcers as determined by tissue bismuth assays. CBS and gastric glycoprotein formed an in vitro complex which markedly retarded the migration of H+. One of the mechanisms by which CBS promotes ulcer healing is through its behaviour as a diffusion barrier to hydrochloric acid.en_US
dc.languageengen_US
dc.relation.ispartofScandinavian Journal of Gastroenterology, Supplementen_US
dc.subject.meshAnti-Ulcer Agents - Metabolism - Pharmacologyen_US
dc.subject.meshBismuth - Metabolism - Pharmacologyen_US
dc.subject.meshDiffusionen_US
dc.subject.meshElectrochemistryen_US
dc.subject.meshGastric Acid - Metabolismen_US
dc.subject.meshGlycoproteins - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshMucus - Metabolismen_US
dc.subject.meshOrganometallic Compoundsen_US
dc.subject.meshStomach Ulcer - Metabolismen_US
dc.titleA potential mechanism of action of colloidal bismuth subcitrate: Diffusion barrier to hydrochloric aciden_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6962540-
dc.identifier.scopuseid_2-s2.0-0020400031en_US
dc.identifier.volume17en_US
dc.identifier.issue80en_US
dc.identifier.spage17en_US
dc.identifier.epage21en_US
dc.publisher.placeNorwayen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.issnl0085-5928-

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