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- Publisher Website: 10.1111/j.1440-1681.1989.tb01530.x
- Scopus: eid_2-s2.0-0024437211
- PMID: 2523766
- WOS: WOS:A1989U211800001
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Article: Changes in met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary in diabetic rats: Effects of insulin therapy
Title | Changes in met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary in diabetic rats: Effects of insulin therapy |
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Authors | |
Keywords | alloxan‐diabetes hypothalamus male rat met‐enkephalin pituitary β‐endorphin |
Issue Date | 1989 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 2, p. 65-75 How to Cite? |
Abstract | Immunoreactive (IR)-met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary were measured in alloxan-diabetic rats with or without insulin treatment. Both IR-met-enkephalin and IR-β-endorphin in the pituitary were substantially reduced in alloxan-diabetic rats 1 month after treatment. Hypothalamic IR-β-endorphin content was also significantly lower. Gel-filtration chromatography showed that the peaks co-eluting with met-enkephalin precursor, met-enkephalin and β-endorphin were lower in the pituitaries from the diabetic rats, whereas the peaks co-eluting with β-endorphin precursor and β-lipotropin were not. In another experiment, the IR-β-endorphin contents of the neuro-intermediate lobe and hypothalamus, but not the anterior lobe were significantly lowered in diabetic rats, whereas IR-met-enkephalin contents were significantly reduced in both the anterior and neuro-intermediate lobe. All these changes were reversed by insulin treatment. As a decrease in general protein synthesis could not explain the recorded changes, these results suggest a possible direct role of insulin in regulating the opioid peptide content of the hypothalamus and pituitary. |
Persistent Identifier | http://hdl.handle.net/10722/171531 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tang, F | en_US |
dc.date.accessioned | 2012-10-30T06:15:33Z | - |
dc.date.available | 2012-10-30T06:15:33Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 2, p. 65-75 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171531 | - |
dc.description.abstract | Immunoreactive (IR)-met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary were measured in alloxan-diabetic rats with or without insulin treatment. Both IR-met-enkephalin and IR-β-endorphin in the pituitary were substantially reduced in alloxan-diabetic rats 1 month after treatment. Hypothalamic IR-β-endorphin content was also significantly lower. Gel-filtration chromatography showed that the peaks co-eluting with met-enkephalin precursor, met-enkephalin and β-endorphin were lower in the pituitaries from the diabetic rats, whereas the peaks co-eluting with β-endorphin precursor and β-lipotropin were not. In another experiment, the IR-β-endorphin contents of the neuro-intermediate lobe and hypothalamus, but not the anterior lobe were significantly lowered in diabetic rats, whereas IR-met-enkephalin contents were significantly reduced in both the anterior and neuro-intermediate lobe. All these changes were reversed by insulin treatment. As a decrease in general protein synthesis could not explain the recorded changes, these results suggest a possible direct role of insulin in regulating the opioid peptide content of the hypothalamus and pituitary. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | alloxan‐diabetes | - |
dc.subject | hypothalamus | - |
dc.subject | male rat | - |
dc.subject | met‐enkephalin | - |
dc.subject | pituitary | - |
dc.subject | β‐endorphin | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Body Weight - Drug Effects | en_US |
dc.subject.mesh | Chromatography, Gel | en_US |
dc.subject.mesh | Diabetes Mellitus, Experimental - Drug Therapy - Metabolism | en_US |
dc.subject.mesh | Enkephalin, Methionine - Analysis - Metabolism | en_US |
dc.subject.mesh | Hypothalamus - Metabolism | en_US |
dc.subject.mesh | Insulin - Therapeutic Use | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Organ Size - Drug Effects | en_US |
dc.subject.mesh | Pituitary Gland - Metabolism | en_US |
dc.subject.mesh | Radioimmunoassay | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Beta-Endorphin - Analysis - Metabolism | en_US |
dc.title | Changes in met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary in diabetic rats: Effects of insulin therapy | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, F:ftang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, F=rp00327 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1989.tb01530.x | - |
dc.identifier.pmid | 2523766 | - |
dc.identifier.scopus | eid_2-s2.0-0024437211 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 65 | en_US |
dc.identifier.epage | 75 | en_US |
dc.identifier.isi | WOS:A1989U211800001 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Tang, F=7201979770 | en_US |
dc.identifier.issnl | 0305-1870 | - |