File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1161/01.HYP.13.6.658
- Scopus: eid_2-s2.0-0024360030
- PMID: 2661425
- WOS: WOS:A1989AA58200002
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Endothelium and control of vascular function. State of the art lecture
Title | Endothelium and control of vascular function. State of the art lecture |
---|---|
Authors | |
Keywords | Endothelium-derived contracting factors Endothelium-derived relaxing factors Hypertension |
Issue Date | 1989 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 1989, v. 13 n. 6 II, p. 658-667 How to Cite? |
Abstract | The response of isolated blood vessels to a variety of vasoactive agonists is modulated by the presence of endothelial cells. Indeed, these cells can release both dilator and constrictor substances. The major endothelium-derived relaxing factor may be nitric oxide, which activates soluble guanylate cyclase in the smooth muscle, although the endothelial cells also secrete an unidentified hyperpolarizing factor. Among the natural stimuli for the release of endothelium-derived relaxing factors are circulating hormones, platelet products, thrombin, shear stress, and certain autacoids. Endothelium-derived relaxing factors may contribute to the regulation of the release of atrial natriuretic factor and renin. The endothelial cells can also release constricting factors; among the likely candidates are superoxide anions or the peptide endothelin. In hypertensive blood vessels, the ability to release endothelium-derived relaxing factors but not endothelium-derived contracting factors is blunted. |
Persistent Identifier | http://hdl.handle.net/10722/170919 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.827 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:25Z | - |
dc.date.available | 2012-10-30T06:11:25Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Hypertension, 1989, v. 13 n. 6 II, p. 658-667 | en_US |
dc.identifier.issn | 0194-911X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170919 | - |
dc.description.abstract | The response of isolated blood vessels to a variety of vasoactive agonists is modulated by the presence of endothelial cells. Indeed, these cells can release both dilator and constrictor substances. The major endothelium-derived relaxing factor may be nitric oxide, which activates soluble guanylate cyclase in the smooth muscle, although the endothelial cells also secrete an unidentified hyperpolarizing factor. Among the natural stimuli for the release of endothelium-derived relaxing factors are circulating hormones, platelet products, thrombin, shear stress, and certain autacoids. Endothelium-derived relaxing factors may contribute to the regulation of the release of atrial natriuretic factor and renin. The endothelial cells can also release constricting factors; among the likely candidates are superoxide anions or the peptide endothelin. In hypertensive blood vessels, the ability to release endothelium-derived relaxing factors but not endothelium-derived contracting factors is blunted. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | en_US |
dc.relation.ispartof | Hypertension | en_US |
dc.subject | Endothelium-derived contracting factors | - |
dc.subject | Endothelium-derived relaxing factors | - |
dc.subject | Hypertension | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Factors - Physiology | en_US |
dc.subject.mesh | Blood Vessels - Drug Effects - Physiology | en_US |
dc.subject.mesh | Endothelins | en_US |
dc.subject.mesh | Endothelium, Vascular - Cytology - Metabolism - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Cytology - Physiology | en_US |
dc.subject.mesh | Nitric Oxide | en_US |
dc.subject.mesh | Peptides - Metabolism - Physiology | en_US |
dc.subject.mesh | Vasodilation | en_US |
dc.title | Endothelium and control of vascular function. State of the art lecture | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.HYP.13.6.658 | - |
dc.identifier.pmid | 2661425 | - |
dc.identifier.scopus | eid_2-s2.0-0024360030 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 6 II | en_US |
dc.identifier.spage | 658 | en_US |
dc.identifier.epage | 667 | en_US |
dc.identifier.isi | WOS:A1989AA58200002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0194-911X | - |