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- Publisher Website: 10.1016/j.cbpa.2009.11.015
- Scopus: eid_2-s2.0-77949889854
- PMID: 20018553
- WOS: WOS:000277110800019
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Article: Metal complexes in medicine with a focus on enzyme inhibition
Title | Metal complexes in medicine with a focus on enzyme inhibition |
---|---|
Authors | |
Issue Date | 2010 |
Publisher | Elsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cbi |
Citation | Current Opinion In Chemical Biology, 2010, v. 14 n. 2, p. 255-261 How to Cite? |
Abstract | Since the clinical success of cisplatin and its derivatives, considerable effort has been expended by academics and pharmacological companies to the development of novel metal-based drugs. DNA is believed to be the main target of cisplatin, and there have been extensive studies on the binding between metal complexes and DNA targets. Recently, new light has been shed on the discovery of metal-based drugs that inhibit enzymatic activities or even target proteins directly. This review highlights some exciting results published recently on the development of platinum, gold, and ruthenium complexes as enzyme inhibitors for potential therapeutic applications. © 2009 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168443 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.328 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Che, CM | en_US |
dc.contributor.author | Siu, FM | en_US |
dc.date.accessioned | 2012-10-08T03:18:59Z | - |
dc.date.available | 2012-10-08T03:18:59Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Current Opinion In Chemical Biology, 2010, v. 14 n. 2, p. 255-261 | en_US |
dc.identifier.issn | 1367-5931 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168443 | - |
dc.description.abstract | Since the clinical success of cisplatin and its derivatives, considerable effort has been expended by academics and pharmacological companies to the development of novel metal-based drugs. DNA is believed to be the main target of cisplatin, and there have been extensive studies on the binding between metal complexes and DNA targets. Recently, new light has been shed on the discovery of metal-based drugs that inhibit enzymatic activities or even target proteins directly. This review highlights some exciting results published recently on the development of platinum, gold, and ruthenium complexes as enzyme inhibitors for potential therapeutic applications. © 2009 Elsevier Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cbi | en_US |
dc.relation.ispartof | Current Opinion in Chemical Biology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coordination Complexes - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Enzyme Inhibitors - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Gold Compounds - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Platinum Compounds - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Ruthenium Compounds - Pharmacology - Therapeutic Use | en_US |
dc.title | Metal complexes in medicine with a focus on enzyme inhibition | en_US |
dc.type | Article | en_US |
dc.identifier.email | Che, CM:cmche@hku.hk | en_US |
dc.identifier.email | Siu, FM:fmsiu@hku.hk | en_US |
dc.identifier.authority | Che, CM=rp00670 | en_US |
dc.identifier.authority | Siu, FM=rp00776 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.cbpa.2009.11.015 | en_US |
dc.identifier.pmid | 20018553 | - |
dc.identifier.scopus | eid_2-s2.0-77949889854 | en_US |
dc.identifier.hkuros | 171403 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77949889854&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 255 | en_US |
dc.identifier.epage | 261 | en_US |
dc.identifier.isi | WOS:000277110800019 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Che, CM=7102442791 | en_US |
dc.identifier.scopusauthorid | Siu, FM=6701518489 | en_US |
dc.identifier.citeulike | 6407000 | - |
dc.identifier.issnl | 1367-5931 | - |