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Article: Influenza A virus NS1 protein does not suppress RNA interference in mammalian cells

TitleInfluenza A virus NS1 protein does not suppress RNA interference in mammalian cells
Authors
Kok, KHJin, DY
KeywordsSpecies Index: Influenza A Virus
Mammalia
Orthomyxoviridae
Issue Date2006
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 2006, v. 87 n. 9, p. 2639-2644 How to Cite?
DOI: http://dx.doi.org/10.1099/vir.0.81764-0
AbstractInfluenza A virus NS1 protein has been shown to suppress RNA interference (RNAi) in plants and Drosophila. Although it has not been demonstrated experimentally, NS1 has also been thought to inhibit RNAi in mammals as well as being an antagonist of interferon. In this study, the influence of NS1 protein from influenza virus strain A/WSN/33 on RNAi in mammalian cells was investigated. While transiently or stably expressed NS1 was fully competent to inhibit the interferon pathway in cultured cells, it did not suppress RNAi-mediated silencing of different reporter genes. These findings imply a significant difference in RNAi mechanism between mammals and plants. © 2006 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/132361
ISSN
0022-1317
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 0.990
ISI Accession Number ID
WOS:000239939900022
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKok, KHen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2011-03-28T09:23:35Z-
dc.date.available2011-03-28T09:23:35Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of General Virology, 2006, v. 87 n. 9, p. 2639-2644en_HK
dc.identifier.issn0022-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132361-
dc.description.abstractInfluenza A virus NS1 protein has been shown to suppress RNA interference (RNAi) in plants and Drosophila. Although it has not been demonstrated experimentally, NS1 has also been thought to inhibit RNAi in mammals as well as being an antagonist of interferon. In this study, the influence of NS1 protein from influenza virus strain A/WSN/33 on RNAi in mammalian cells was investigated. While transiently or stably expressed NS1 was fully competent to inhibit the interferon pathway in cultured cells, it did not suppress RNAi-mediated silencing of different reporter genes. These findings imply a significant difference in RNAi mechanism between mammals and plants. © 2006 SGM.en_HK
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_HK
dc.relation.ispartofJournal of General Virologyen_HK
dc.subjectSpecies Index: Influenza A Virusen_US
dc.subjectMammaliaen_US
dc.subjectOrthomyxoviridaeen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshDNA, Viral - geneticsen_HK
dc.subject.meshGenes, Reporteren_HK
dc.subject.meshHeLa Cellsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A virus - genetics - pathogenicity - physiologyen_HK
dc.subject.meshInterferons - antagonists & inhibitorsen_HK
dc.subject.meshPlasmids - geneticsen_HK
dc.subject.meshRNA Interferenceen_HK
dc.subject.meshRecombinant Proteins - genetics - metabolismen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshViral Nonstructural Proteins - genetics - physiologyen_HK
dc.titleInfluenza A virus NS1 protein does not suppress RNA interference in mammalian cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailKok, KH:khkok@hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityKok, KH=rp01455en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1099/vir.0.81764-0en_HK
dc.identifier.pmid16894203-
dc.identifier.scopuseid_2-s2.0-33747366052en_HK
dc.identifier.hkuros119560-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747366052&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume87en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2639en_HK
dc.identifier.epage2644en_HK
dc.identifier.isiWOS:000239939900022-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKok, KH=7006862631en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.issnl0022-1317-

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