Ivabradine induces BRCAness in BRCA1/2 wild type triple-negative and ER-positive breast cancer, leading to PARP inhibitor sensitivity

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Grant Data
Project Title
Ivabradine induces BRCAness in BRCA1/2 wild type triple-negative and ER-positive breast cancer, leading to PARP inhibitor sensitivity
Principal Investigator
Professor Khoo, Ui Soon   (Principal Investigator (PI))
Co-Investigator(s)
Professor Yam Judy Wai Ping   (Co-Investigator)
Dr Tsoi Ho   (Co-Investigator)
Duration
36
Start Date
2024-07-15
Amount
1558075
Conference Title
Ivabradine induces BRCAness in BRCA1/2 wild type triple-negative and ER-positive breast cancer, leading to PARP inhibitor sensitivity
Keywords
breast cancer, PARP inhibitor, HCN inhibitor, BRCAness, non-BRCA mutated cancer
Discipline
CancerMolecular Biology
Panel
Biology and Medicine (M)
HKU Project Code
17106824
Grant Type
General Research Fund (GRF) 2024/25
Funding Year
2024
Status
On-going
Objectives
Refer to ES