Effect of SARS-CoV-2 spike protein on vascular function under physiological and hypertensive conditions

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Grant Data
Project Title
Effect of SARS-CoV-2 spike protein on vascular function under physiological and hypertensive conditions
Principal Investigator
Professor Leung, Susan Wai Sum   (Principal Investigator (PI))
Co-Investigator(s)
Professor Chan Michael Chi Wai   (Co-Investigator)
Professor Hui Pui Yan   (Co-Investigator)
Duration
36
Start Date
2024-06-01
Amount
1495360
Conference Title
Effect of SARS-CoV-2 spike protein on vascular function under physiological and hypertensive conditions
Keywords
ageing, angiotensin converting, endothelial function, inflammation, oxidative stress
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
23221062
Grant Type
Health and Medical Research Fund 2022
Funding Year
2022
Status
On-going
Objectives
SARS-CoV-2 spike protein is present in endothelial cells (ECs) in patients with COVID-19, and in plasma of patients developing long COVID and cardiovascular complications following COVID-vaccination. Our preliminary date suggests that SARS-CoV-2 spike protein activated ECs. Therefore, the present proposal aims to examine the effects of SARS-CoV-2 spike protein on endothelial function.