Molecular Mechanism of RNA Transport and Specificity of their Spatial Distribution in Neuron

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Grant Data
Project Title
Molecular Mechanism of RNA Transport and Specificity of their Spatial Distribution in Neuron
Principal Investigator
Professor Li, Xuechen   (Co-Principal Investigator (Co-PI) (for projects led by other university))
Duration
36
Start Date
2023-06-01
Amount
620000
Conference Title
Molecular Mechanism of RNA Transport and Specificity of their Spatial Distribution in Neuron
Keywords
1) Intracellular transport 2) Neuron 3) Synapse 4) Signal transduction
Discipline
Neurobiology and Neuromedicine
Panel
Biology and Medicine (M)
HKU Project Code
C1024-22G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project 2022/2023
Status
On-going
Objectives
To investigate the roles of lncRNA and arginine methylation in regulating mRNA transport by KIF5BTo characterize the heterogeneous transport of dendritic mRNAs and identify the underlying mechanismTo determine the experience-dependent localization of different RBPs in KIF5B conditional knockout mice in vivo