Characterization of CASC11, a long noncoding RNA (LncRNA) as a new generation of RNA therapeutics in hepatocellular carcinoma
Grant Data
Project Title
Characterization of CASC11, a long noncoding RNA (LncRNA) as a new generation of RNA therapeutics in hepatocellular carcinoma
Principal Investigator
Dr Wong, Lok Sze
(Principal Investigator (PI))
Co-Investigator(s)
Professor Wong Chun Ming
(Co-principal investigator)
Professor Ng Irene Oi Lin
(Co-principal investigator)
Duration
36
Start Date
2023-07-03
Amount
1500000
Conference Title
Characterization of CASC11, a long noncoding RNA (LncRNA) as a new generation of RNA therapeutics in hepatocellular carcinoma
Keywords
hepatocellular carcinoma, MYC, Long noncoding RNAs, RNA therapeutics, CRISPR library screening
Discipline
Biology and Medicine
Panel
Biology and Medicine (M)
HKU Project Code
10212786
Grant Type
Health and Medical Research Fund 2021
Funding Year
2023
Status
On-going
Objectives
Hepatocellular carcinoma (HCC) is one of the lethal cancers in Hong Kong. Resistance to chemotherapy and immunotherapy remains a major barrier to effective treatment, thus highlighting the need for effective drug targets and better clinical prognosticators for HCC treatment. Given our encouraging findings showing the critical role of long noncoding RNA (lncRNA) in HCC, in this proposal, we will 1) interrogate the significance of lncRNA (i.e. CASC11) in different subtypes of HCC patients, and 2) explore how lncRNA-based therapeutics synergizes with chemotherapy and immunotherapy to sensitize HCC tumor shrinkage.