Therapeutic strategy targeting THY1+ fibroblasts mediated osteoclastogenesis and inflammation in early osteoarthritis based on progression at single cell resolution
Grant Data
Project Title
Therapeutic strategy targeting THY1+ fibroblasts mediated osteoclastogenesis and inflammation in early osteoarthritis based on progression at single cell resolution
Principal Investigator
Professor Chan, Ping Keung
(Principal Investigator (PI))
Co-Investigator(s)
Cheung Yim Ling Amy
(Co-Investigator)
Professor Chen Di
(Co-Investigator)
Dr Su Zezhuo
(Co-principal investigator)
Professor Lu William Weijia
(Co-principal investigator)
Professor Chiu Peter Kwong Yuen
(Co-principal investigator)
Dr. LI Li
(Co-Investigator)
Professor Fu Chun Him Henry
(Co-principal investigator)
Chan Wai Kwan Vincent
(Co-Investigator)
Professor Ho Joshua Wing Kei
(Co-principal investigator)
Duration
36
Start Date
2023-09-01
Amount
1430410
Conference Title
Therapeutic strategy targeting THY1+ fibroblasts mediated osteoclastogenesis and inflammation in early osteoarthritis based on progression at single cell resolution
Keywords
Osteoarthritis, Single-cell sequencing, Therapy, Synovial fluid, THY1
Discipline
Biology and Medicine
Panel
Biology and Medicine (M)
HKU Project Code
10212836
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
Our first objective is to validate THY1+ fibroblasts as an early marker of osteoarthritis. The second goal of this study focuses on tracing the lineage of THY1+ fibroblasts using endogenous mitochondrial somatic variants. Toward that end, we will test therapeutic potentials of inhibiting THY1+ fibroblasts mediated osteoclastogenesis and inflammation via blockage of RANKL and CXCL12 in vivo respectively.