The role of SIRT7 mediated de-acylation in controlling Th17 differentiation and autoimmune diseases
Grant Data
Project Title
The role of SIRT7 mediated de-acylation in controlling Th17 differentiation and autoimmune diseases
Principal Investigator
Dr Bao, Xiucong
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chan Koon Ho
(Co-principal investigator)
Cao Guangchao
(Co-Investigator)
Duration
36
Start Date
2023-05-01
Amount
1499888
Conference Title
The role of SIRT7 mediated de-acylation in controlling Th17 differentiation and autoimmune diseases
Keywords
Autoimmune diseases, Multiple sclerosis, Th17, Sirtuin, Histone acylations, Posttranslational modifications
Discipline
Others - Medicine, Dentistry and Health
Panel
Biology and Medicine (M)
HKU Project Code
10212456
Grant Type
Health and Medical Research Fund 2021
Funding Year
2022
Status
On-going
Objectives
Th17 cells-mediated proinflammatory responses play critical roles in the pathogenesis of many autoimmune diseases, especially multiple sclerosis (MS). However, the underlying mechanisms have not been fully defined. Our preliminary data demonstrated that SIRT7, an epigenetic regulator promotes the differentiation of Th17 cells and aggravates the pathogenesis of experimental autoimmune encephalomyelitis (EAE, a mouse model of MS). In this project, we aim to decipher the role of SIRT7-mediated de-acylation in controlling Th17 differentiation and autoimmune diseases.