Mechanisms underlying eye movement desensitization and reprocessing (EMDR) on fear memory trace erasure
Grant Data
Project Title
Mechanisms underlying eye movement desensitization and reprocessing (EMDR) on fear memory trace erasure
Principal Investigator
Dr Lai, Sau Wan Cora
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lam Lok Man Charlene
(Co-Investigator)
Dr Chang Raymond Chuen Chung
(Co-Investigator)
Professor Chan Ying Shing
(Co-Investigator)
Duration
36
Start Date
2022-10-01
Amount
1499748
Conference Title
Mechanisms underlying eye movement desensitization and reprocessing (EMDR) on fear memory trace erasure
Presentation Title
Keywords
Alternating bilateral stimulation, Dendritic spine plasticity, Eye movement desensitization and reprocessing, Fear conditioning, Optogenetics, post-traumatic stress disorder
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
09200966
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2021
Status
On-going
Objectives
To investigate the effects of an animal model of eye movement desensitization and reprocessing (EMDR) on fear memory trace erasure. Hypothesis to be tested: EMDR has been shown to be effective for the treatment of post-traumatic stress disorder (PTSD). Here we hypothesize that EMDR-induced fear memory erasure involves modification of cortical memory traces and that the frontal cortex plays an essential role in EMDR.