Ferroptosis as potential target in ovarian cancer therapy
Grant Data
Project Title
Ferroptosis as potential target in ovarian cancer therapy
Principal Investigator
Professor Cheung, Annie Nga Yin
(Principal Investigator (PI))
Co-Investigator(s)
Professor Ngan Hextan Yuen Sheung
(Co-Investigator)
Dr Wong Oscar Gee Wan
(Co-Investigator)
Duration
24
Start Date
2022-10-01
Amount
1498248
Conference Title
Ferroptosis as potential target in ovarian cancer therapy
Presentation Title
Keywords
cancer, Cisplatin, Ferroptosis, ovarian, Ovarian cancer, therapy
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
09201976
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2021
Status
On-going
Objectives
Ovarian cancer is a malignancy of high mortality, significantly attributed to relatively common chemoresistance. Ferroptosis, a recently described regulated cell death, is emerging as important in cancer development and response to therapy. A few US-FDA-approved drugs with history of use in various diseases are found to induce ferroptosis. This study aims to explore possible repurposing of these drugs for ovarian cancer therapy, either as single agent or as adjunct to chemotherapy. Moreover, the mechanism of ferroptosis resistance will be investigated focusing on a candidate ferroptosis regulator gene involved in lipid metabolism that is identified in pilot study.