What happens after Kasai portoenterostomy? – In vitro study of cholangiopathy in post-operative biliary atresia using organoid models and single cell transcriptome analysis
Grant Data
Project Title
What happens after Kasai portoenterostomy? – In vitro study of cholangiopathy in post-operative biliary atresia using organoid models and single cell transcriptome analysis
Principal Investigator
Dr Chung, Ho Yu
(Principal Investigator (PI))
Co-Investigator(s)
Professor Wong Kenneth Kak Yuen
(Co-Investigator)
Emeritus Professor Tam Paul Kwong Hang
(Co-Investigator)
Dr Lui Chi Hang
(Co-Investigator)
Duration
36
Start Date
2022-01-01
Amount
752578
Conference Title
What happens after Kasai portoenterostomy? – In vitro study of cholangiopathy in post-operative biliary atresia using organoid models and single cell transcriptome analysis
Presentation Title
Keywords
Biliary atresia, Cholangiopathy, Kasai portoenterostomy, Organoids, Transcriptome
Discipline
Surgical Research,Paediatrics
Panel
Biology and Medicine (M)
HKU Project Code
17107521
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 To determine if there is a correlation between the morphology of BA liver organoids and the clinical conditions after Kasai portoenterostomy 2 To elucidate the expression of common or rare transcripts in liver samples from BA at various stages after Kasai portoenterostomy 3 To determine if there is a relationship between abnormal gene expression and post-operative cholangiopathy