Anticoagulation strategies for cancer associated thrombosis
Grant Data
Project Title
Anticoagulation strategies for cancer associated thrombosis
Principal Investigator
Professor Chan, Esther Wai Yin
(Principal Investigator (PI))
Co-Investigator(s)
Professor Ngan Kai Cheong Roger
(Co-Investigator)
Professor Wong Ian Chi Kei
(Co-Investigator)
Dr Lam Ka On
(Co-Investigator)
Professor Chan Lam Stephen
(Co-Investigator)
Professor Lee Victor Ho Fun
(Co-Investigator)
Duration
42
Start Date
2021-10-01
Amount
985412
Conference Title
Anticoagulation strategies for cancer associated thrombosis
Keywords
anticoagulation, bleeding, cancer associated thrombosis, secondary VTE prophylaxis, treatment switch
Discipline
EpidemiologyCancer
Panel
Biology and Medicine (M)
HKU Project Code
17108621
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 The overall objective is to evaluate the effectiveness and safety of continuous use of low-molecular weight heparin (LMWH) versus switching to non-vitamin K antagonists (NOACs) following the use of LMWH, for prevention of recurrent venous thromboembolism (VTE) in patients with cancer associated thrombosis (CAT). Specifically: a) To compare the risk of recurrent VTE and bleeding associated with continuous use of LMWH versus switching to NOACs in patients with CAT. b) To characterise the risk-benefit profile associated with different durations of anticoagulant use in patients with CAT. c) To assess the risk of mortality and healthcare utilisation associated with continuous use of LMWH versus switching to NOACs in patients with CAT.