Elucidation of the immunosuppressive landscape and subclonal heterogeneity in hepatocellular carcinoma by single-cell RNA sequencing
Grant Data
Project Title
Elucidation of the immunosuppressive landscape and subclonal heterogeneity in hepatocellular carcinoma by single-cell RNA sequencing
Principal Investigator
Professor Ho, Daniel Wai Hung
(Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin
(Co-Investigator)
Dr Chan Lo Kong
(Co-Investigator)
Duration
42
Start Date
2022-01-01
Amount
899732
Conference Title
Elucidation of the immunosuppressive landscape and subclonal heterogeneity in hepatocellular carcinoma by single-cell RNA sequencing
Keywords
HCC, Liver cancer, next-generation sequencing, scRNA-seq, single-cell sequencing
Discipline
CancerGastroenterology/Hepatobiliary
Panel
Biology and Medicine (M)
HKU Project Code
17100021
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 Comprehensively profiling an expanded cohort of HBV-associated HCC tumors by single-cell RNA sequencing 2 Investigating the multifaceted landscapes and cell-cell interactions between the tumor cells and immune microenvironment 3 Validating the immunosuppressive LAIR1 expression by M2 macrophages and other discovery findings in an expanded cohort and determining the clinicopathologic and prognostic significance