Activation of PIP2-IP3 Signaling Pathway in Ankylosing Spondylitis
Grant Data
Project Title
Activation of PIP2-IP3 Signaling Pathway in Ankylosing Spondylitis
Principal Investigator
Dr Leung, Victor Yu Leong
(Principal Investigator (PI))
Co-Investigator(s)
Professor Lu William Weijia
(Co-Investigator)
Dr Sun Tianhao
(Co-Investigator)
Professor Chen Di
(Co-Investigator)
Dr Yi Dan
(Co-Investigator)
Duration
36
Start Date
2021-09-01
Amount
1325732
Conference Title
Activation of PIP2-IP3 Signaling Pathway in Ankylosing Spondylitis
Presentation Title
Keywords
AKAP13, Ankylosing spondylitis, Autoimmune disease, PIP2-IP3 signaling pathway, PIP5K1C
Discipline
Orthopaedics/Traumatology,Genetic Disease
Panel
Biology and Medicine (M)
HKU Project Code
17101821
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 Aim 1: To determine if mutation of Pip5k1c or Akap13 leads to AS phenotype; 1A: To determine if Pip5k1c and Akap13 single mutant mice exhibit AS phenotype. 1B: To determine if Pip5k1c/Akap13 d-MT mice display AS phenotype. 2 Aim 2: To determine if Pip5k1c and PLC are critical molecular targets for AS drug development. 2A: To determine if PIP2-IP3 signaling pathway is activated in Pip5k1c and Akap13 mutant mice. 2B: To determine if inhibition of Pip5k1c or PLC could relieve the AS phenotype in AS mouse model.