Selection of DNA-encoded chemical library against protein targets with distal ligand-binding sites for multivalent ligand discovery
Grant Data
Project Title
Selection of DNA-encoded chemical library against protein targets with distal ligand-binding sites for multivalent ligand discovery
Principal Investigator
Professor Li, Xiaoyu
(Principal Investigator (PI))
Co-Investigator(s)
Professor Li Xuechen
(Co-Investigator)
Duration
36
Start Date
2021-10-01
Amount
936415
Conference Title
Selection of DNA-encoded chemical library against protein targets with distal ligand-binding sites for multivalent ligand discovery
Presentation Title
Keywords
DNA display, DNA-encoded chemical library, drug discovery, high-throughput screening, Multivalency
Discipline
Chemical Sciences,Drug Discovery and Delivery
Panel
Physical Sciences (P)
HKU Project Code
17300321
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 To develop a method capable of assembling DNA-encoded multivalent ligand libraries (DEMLs) with high structural and configurational diversity; 2 To design a series of library scaffolds to match the valency and symmetry of different multivalent biological systems; 3 To build a series of large-scale DEMLs at the multi-billion-compound scale; 4 To develop a method capable of selecting DEMLs against multivalent biological targets; 5 To identify potent and specific ligands for representative multivalent protein targets, and also validate the biological functions of the identified ligands; 6 To summarize the results and identify future research opportunities for more in-depth studies, especially the ligands with potential for drug development.