Do bisphosphonates reduce risk of dementia? A real-world pharmacoepidemiology study in Hong Kong and the United Kingdom

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Grant Data
Project Title
Do bisphosphonates reduce risk of dementia? A real-world pharmacoepidemiology study in Hong Kong and the United Kingdom
Principal Investigator
Dr Sing, Chor Wing   (Principal Investigator (PI))
Co-Investigator(s)
Dr Cheung Ching Lung   (Co-Investigator)
Dr Chan Koon Ho   (Co-Investigator)
Dr Lau Cheuk Yin Wallis   (Co-Investigator)
Dr Chiu Ka Chun Patrick   (Co-Investigator)
Duration
24
Start Date
2021-11-01
Amount
555896
Conference Title
Do bisphosphonates reduce risk of dementia? A real-world pharmacoepidemiology study in Hong Kong and the United Kingdom
Presentation Title
Keywords
Alzheimer’s disease, bisphosphonates, dementia, osteoporosis, pharmacoepidemiology, Real-world
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
18192451
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2020
Status
On-going
Objectives
Objectives To evaluate the relationship between use of bisphosphonates and the risk of dementia in older people in Hong Kong and the United Kingdom (UK). Hypothesis to be tested The use of bisphosphonates is associated with reduced risk of dementia. Design and subjects The proposed study will use the real-world data from large healthcare databases in Hong Kong and the UK to test for the hypothesis. Patients aged 60 or above, with an initial osteoporosis and/or major fragility fractures from 2005 to 2020, will be included for analysis. In the primary analysis, patients receiving bisphosphonates will be compared with those without any treatment of anti-osteoporosis medication. In the secondary analysis, the comparison group will be patients receiving other non-bisphosphonates anti-osteoporosis medications. A time-dependent propensity score matching approach will be used to balance the characteristics between the comparison groups. Instruments N/A Interventions N/A Main outcome measures The risk of dementia in patients receiving bisphosphonates will be estimated. Data analysis A time-to-event analysis will be conducted using Cox proportional hazard model. Hazard ratio and 95% confidence interval will be estimated. Expected results A lower risk of dementia will be observed in patients receiving bisphosphonates compared with the comparison groups. Results in Hong Kong and the UK will be consistent.