Prediction of metabolic and cardiovascular complications in women with polycystic ovary syndrome: a longitudinal study

Professor Li, Raymond Hang Wun   (Principal Investigator (PI))

Professor Ng Ernest Hung Yu   (Co-Investigator)

Professor Lee Chi Ho Paul   (Co-Investigator)

45

2021-07-15

1113100

Prediction of metabolic and cardiovascular complications in women with polycystic ovary syndrome: a longitudinal study

Androgen excess, Antral follicle count, Early atherosclerosis, Metabolic syndrome, Non-alcoholic fatty liver disease, Polycystic ovary syndrome

Others - Medicine, Dentistry and Health

08192856

Health and Medical Research Fund - Full Grant

2020

On-going

Objectives: To investigate the predictive roles of androgen indices, antral follicle count (AFC) and serum anti-Mullerian hormone (AMH) levels on the 10-year risk of cardio-metabolic complications in women with polycystic ovary syndrome (PCOS) Hypotheses to be tested: Free androgen index, AFC and serum AMH levels are all significant predictors of metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and early atherosclerosis at the 10th year follow-up. Design and subjects: Longitudinal follow-up study on a cohort of women diagnosed with PCOS (n=467) and healthy controls (n=255), which had been prospectively recruited between 2011 and 2013. Instruments: At recruitment, the subjects (PCOS and controls) underwent baseline anthropometric, sonographic, hormonal and metabolic assessment. Interventions: The subjects will attend the 10th year follow-up in 2021 to 2023 with the same assessments repeated. In addition, controlled attenuation parameter (CAP) will be measured by vibration-controlled transient elastography as a measure of hepatic steatosis. Carotid intimal-media thickness (CIMT) and brachial-ankle pulse wave velocity (baPWV) will be measured as indices of early atherosclerotic change. Main outcome measures: Occurrence of MetS, NAFLD and early atherosclerotic changes at the 10th year follow-up. Data analysis and expected results: Rates of MetS, NAFLD and early atherosclerosis will be compared between PCOS women and controls. The predictive role of free androgen index, AFC and serum AMH on the 10-year risk of MetS, NAFLD and early atherosclerosis will be determined by receiver-operator characteristic curve and multivariate logistic regression. A prediction model will be derived by the logistic regression model.