Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients using Cardiovascular Magnetic Resonance

Professor Ng, Ming Yen   (Principal Investigator (PI))

Dr Wu Tak Chiu   (Co-Investigator)

Dr Liu Wai To Raymond   (Co-Investigator)

Dr Cheung Chi Wan Stephen   (Co-Investigator)

Dr Chan Wing Sze Carmen   (Co-Investigator)

Dr Chan Wai Man Johnny   (Co-Investigator)

Dr Lung Kwok Cheung   (Co-Investigator)

Dr Wu Ka Lun Alan   (Co-Investigator)

Professor Siu David Chung Wah   (Co-Investigator)

Professor Hung Fan Ngai Ivan   (Co-Investigator)

36

2021-09-20

1499640

Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients using Cardiovascular Magnetic Resonance

Cardiovascular Magnetic Resonance, Coronavirus disease 2019, COVID-19, Myocardial Inflammation

Others - Medicine, Dentistry and Health

18192881

Health and Medical Research Fund - Full Grant

2020

On-going

Objectives: Determine the clinical significance and longer term impact of myocardial involvement in patients with COVID-19 compared to age and gender matched controls and recovered non-COVID-19 patients with viral respiratory illness (VRI). Hypothesis to be tested: Recovered COVID-19 patients will show significantly more myocardial involvement early and up to 1 year after recovery compared to VRI patients and age and gender matched controls. Design and subjects: Prospective longitudinal cohort study comprising 70 recovered COVID-19 patients, 21 VRI patients and 21 age and gender matched controls. Instruments: Cardiac magnetic resonance (CMR), 6-minute walking test (6MWT) and blood tests (including white cell count, C-reactive protein, NT-proBNP, lactate dehydrogenase, troponin). Interventions: Observational study using the above instruments. No intervention will be used. Main outcome measures: CMR tissue characterisation (ie. T1/T2 mapping, extracellular volume [ECV], late gadolinium enhancement [LGE], 6 minute walking test. Data analysis: Comparison between COVID-19 patients, VRI patients and age and gender matched controls’ CMR parameters (ie. ejection fraction, volume, native T1, T2, ECV, LGE), blood markers and 6MWT. A generalised linear model will be used to assess the change in CMR, blood marker and 6WMT parameters over time. Expected results: Recovered COVID-19 patients will have significantly greater myocardial involvement up to 1 year after recovery compared to age and gender matched controls and VRI patients.