Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model
Grant Data
Project Title
Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model
Principal Investigator
Professor Tse, Hung Fat
(Principal Investigator (PI))
Co-Investigator(s)
Professor Esteban Miguel A
(Co-Investigator)
Miss Wei Rui
(Co-Investigator)
Mr Yang Jiayin
(Co-Investigator)
Dr Au Ka Wing
(Co-Investigator)
Duration
11
Start Date
2021-07-15
Completion Date
2022-06-30
Amount
386925
Conference Title
Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model
Keywords
Chimeric Rabbit Model, Familial Hypercholesterolemia, Generation, Human Liver
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
PiH/204/21
Grant Type
Research Talent Hub for ITF Projects (RTH-ITF)
Funding Year
2021
Status
Completed
Objectives
Statins are the first line drugs for lowering LDL-C. However, statins fail to reduce plasma LDL-C adequately in the majority of these patients for prevention of cardiovascular events, and some proportion of patients suffer from significant adverse effects. PCSK9 antibody, an optimising drug for lowering LDL-C, is too expensive to afford by patients. In this project, we are aiming to develop a familial hypercholesterolemia human liver chimeric rabbit model, to test antibody, RNAi, gene therapy and cell therapy approaches, thus providing a platform for developing novel therapies for hypercholesterolemia, to benefit patients and society, and to promote industrial upgrading in drug discovery.