Deciphering the Dichotomous Effects and Molecular Mechanisms of BCL2A1 in Regulating Ovarian Cancer Dissemination

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Grant Data
Project Title
Deciphering the Dichotomous Effects and Molecular Mechanisms of BCL2A1 in Regulating Ovarian Cancer Dissemination
Principal Investigator
Professor Ngan, Hextan Yuen Sheung   (Principal Investigator (PI))
Co-Investigator(s)
Dr Chan David Wai   (Co-Investigator)
Professor Cheung Annie Nga Yin   (Co-Investigator)
Duration
36
Start Date
2020-07-01
Completion Date
2023-06-30
Amount
996285
Conference Title
Deciphering the Dichotomous Effects and Molecular Mechanisms of BCL2A1 in Regulating Ovarian Cancer Dissemination
Keywords
BCL2A1, hypoxia, NFkB signaling, ovarian cancer, peritoneal metastases
Discipline
CancerSignal Transduction
Panel
Biology and Medicine (M)
HKU Project Code
17121220
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
Completed
Objectives
1 To completely decipher the molecular mechanisms of BCL2A1 in regulating ovarian cancer cell survival and growth. 2 To dissect the clinical relevance of BCL2A1 in ovarian cancer metastatic progression. 3 To test the feasibility of using NFkB inhibitors or BCL2A1 targeting approach in impeding metastatic colonization of ovarian cancer cells.