The role of KIF5B in cue- and location-specific dendritic spine plasticity in fear learning and extinction

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Grant Data
Project Title
The role of KIF5B in cue- and location-specific dendritic spine plasticity in fear learning and extinction
Principal Investigator
Dr Lai, Sau Wan Cora   (Principal Investigator (PI))
Co-Investigator(s)
Dr Lai Kwok On   (Co-Investigator)
Professor Huang Jiandong   (Co-Investigator)
Duration
36
Start Date
2021-01-01
Amount
996285
Conference Title
The role of KIF5B in cue- and location-specific dendritic spine plasticity in fear learning and extinction
Presentation Title
Keywords
Dendritic spine clustering, Dendritic spine plasticity, Learning and memory
Discipline
Neuroscience,Neurobiology and Neuromedicine
Panel
Biology and Medicine (M)
HKU Project Code
17102120
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 Aim 1: To investigate the role of KIF5B in baseline dendritic spine plasticity in the frontal association cortex. 2 Aim 2: To investigate the role of KIF5B in cue- and location-specific dendritic spine modifications in the frontal association cortex in fear learning and extinction. 3 Aim 3: To investigate the role of KIF5B in FMRP localization and its effects on dendritic spine plasticity in fear learning.