Development of rapid-responsive carbapenemase sensors for tackling antibiotic resistance

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Grant Data
Project Title
Development of rapid-responsive carbapenemase sensors for tackling antibiotic resistance
Principal Investigator
Professor Li, Xuechen   (Principal Investigator (PI))
Duration
36
Start Date
2020-08-01
Completion Date
2024-07-23
Amount
666512
Conference Title
Development of rapid-responsive carbapenemase sensors for tackling antibiotic resistance
Keywords
antibiotic resistance, carbapenemase, chemical biology, chemiluminescent sensor, fluorescent sensor
Discipline
Chemical SciencesMicrobiology
Panel
Physical Sciences (P)
HKU Project Code
17309420
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
Completed
Objectives
1 Development of small-molecule-based fluorogenic carbapenemase sensors with rapid ""turn-on"" response 2 Establishment of a rapid test protocol for carbapenemase detection in clinical isolates 3 Development of small-molecule-based chemiluminogenic carbapenemase sensors for ultra-high sensitivity