Cycloadditions of Geminally-substituted epoxy and aziridinyl enolsilanes for the synthesis of perhydroazulenes and other frameworks
Grant Data
Project Title
Cycloadditions of Geminally-substituted epoxy and aziridinyl enolsilanes for the synthesis of perhydroazulenes and other frameworks
Principal Investigator
Professor Chiu, Pauline
(Principal Investigator (PI))
Co-Investigator(s)
Dr Scheeff Stephan Jurgen Wolfgang
(Co-Investigator)
Duration
36
Start Date
2021-01-01
Amount
666512
Conference Title
Cycloadditions of Geminally-substituted epoxy and aziridinyl enolsilanes for the synthesis of perhydroazulenes and other frameworks
Presentation Title
Keywords
aziridine, cycloaddition, epoxide, natural products, perhydroazulenes
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17309320
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 To study the reaction conditions to induce intramolecular (4+3) or (3+2) cycloadditions of the S2-type substrates 2 To investigate the scope of electrophile in the intramolecular cycloaddition reactions of the S2-type substrates, including the tether length 3 To investigate the intramolecular cycloaddition reactions of the S2-type substrates with various dienes and alkenes 4 To investigate the intramolecular cycloaddition reactions of the S2-type substrates bearing aziridines 5 To explore the derivations and synthetic potential of the (4+3) and (3+2) cycloadducts 6 To engage in synthetic studies toward the tetraneurins and/or other natural products