Chemoselective peptide cyclization development and application exploration

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Grant Data
Project Title
Chemoselective peptide cyclization development and application exploration
Principal Investigator
Professor Li, Xuechen   (Principal Investigator (PI))
Duration
36
Start Date
2021-01-01
Amount
666512
Conference Title
Chemoselective peptide cyclization development and application exploration
Presentation Title
Keywords
cyclic peptide, peptide cylization, peptide synthesis, stapled peptide
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17303920
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 Structure-activity relationship of OPA-mediated peptide cyclization 2 Explore OPA-cyclic peptides mimicking disulfide cyclic peptides 3 OPA-thiol-amine cyclization for synthesizing stapled peptides 4 Application OPA peptide cyclization for phage display