A randomised double-blind controlled trial on the effect of vitamin D on the ovulation rate of women with polycystic ovary syndrome

Dr Li, Raymond Hang Wun   (Principal Investigator (PI))

Dr Cheung Ching Lung   (Co-Investigator)

Dr Ko Ka Yee Jennifer   (Co-Investigator)

Professor Ng Ernest Hung Yu   (Co-Investigator)

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2021-01-29

1482776

A randomised double-blind controlled trial on the effect of vitamin D on the ovulation rate of women with polycystic ovary syndrome

Anovulation, Polycystic ovary syndrome, Vitamin D

Others - Medicine, Dentistry and Health

07182846

Health and Medical Research Fund - Full Grant

2020

On-going

To assess the effect of vitamin D supplementation on (1) the ovulation rate of women with polycystic ovary syndrome (PCOS), and (2) other reproductive, endocrine and metabolic outcomes after one year of treatment. Hypothesis to be tested: Vitamin D supplementation results in significant improvement in the ovulation rate of women with PCOS either spontaneously or with oral ovulation induction agentDesign and subjects: A randomised double-blind controlled clinical trial. A total of 220 anovulatory women with PCOS diagnosed on the Rotterdam criteria will the recruited.Interventions: Subjects will be randomised to either the (1) vitamin D group or (2) placebo group. Those in the vitamin D group will take Vitamin D 50,000 IU/week for 4 weeks, followed by 50,000 IU once every 2 weeks for 52 weeks, whereas those in the placebo group will take placebo tablets with the same external appearance. Those who remain anovulatory after 6 months will be treated with a 6-month course of letrozole (2.5mg to 7.5 mg for 5 days per cycle titrated according to response) for ovulation induction.