Development of novel DelNS1 bivalent live attenuated vaccines for influenza and other respiratory diseases
Grant Data
Project Title
Development of novel DelNS1 bivalent live attenuated vaccines for influenza and other respiratory diseases
Principal Investigator
Dr Wang, Pui
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Honglin
(Co-Investigator)
Duration
24
Start Date
2020-09-15
Amount
1396496
Conference Title
Development of novel DelNS1 bivalent live attenuated vaccines for influenza and other respiratory diseases
Presentation Title
Keywords
Bivalent vaccine, influenza, live atenuated vaccine, NS1
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
19181052
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
The main objective is to utilize the CA4-DelNS1 LAIV system to develop bivalent flu vaccines which enhance immunity against influenza and other pathogens. Safety, immunogenicity and protective efficacy of bivalent CA4-DelNS1 vectors will be fully evaluated in mice. We will also use CA4-DelNS1 as a master strain to create DelNS1 flu vaccines for other emerging avian influenza strains. Finally, we will explore and address the possible impact of pre-existing immunity on the efficacy of DelNS1 bivalent vaccines.