The role of newly defined blood dendritic cells on HIV infection
Grant Data
Project Title
The role of newly defined blood dendritic cells on HIV infection
Principal Investigator
Dr Zhou, Runhong
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Zhiwei
(Co-Investigator)
Duration
36
Start Date
2020-09-01
Amount
1499244
Conference Title
The role of newly defined blood dendritic cells on HIV infection
Presentation Title
Keywords
CyTOF, DC dysfunction, Dendritic cell, Functional cure, HIV, T cell response
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
19181012
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
For HIV functional cure, Dendritic cells (DCs) play important role on the successful development of therapeutic vaccine and immunotherapy, which have been the research hotspots for achieving sustained HIV suppression. By using the advance approach, taxonomy of DCs in blood have been redefined. This precise classification opens the way for a more accurate view of DCs role in pathologies and provides cues for more specific targeting for therapy. To develop the effective therapeutic vaccine and immunotherapy, it warrants to characterize the lineage and function of newly defined DCs in HIV-infected individuals.