The role of transforming growth factor-beta (TGF-β) on human immunodeficiency virus (HIV) infection and latency
Grant Data
Project Title
The role of transforming growth factor-beta (TGF-β) on human immunodeficiency virus (HIV) infection and latency
Principal Investigator
Dr Mo, Yufei
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Zhiwei
(Co-Investigator)
Duration
36
Start Date
2020-08-01
Amount
1455412
Conference Title
The role of transforming growth factor-beta (TGF-β) on human immunodeficiency virus (HIV) infection and latency
Keywords
AIDS, CD4 T cells, HIV, Latency reservoir, Transform growth factor beta
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
19180642
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
The major hurdle in achieving HIV sterilizing cure is the persistence of latent virus in CD4 T cells. Our study aimed to investigate whether TGF-β up-regulation in patients facilitates HIV infection and latency establishment in different CD4 T cells subsets via mediating HIV co-receptors and chemokine receptors expressions.