Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR
Grant Data
Project Title
Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR
Principal Investigator
Dr Gao, Peng
(Principal Investigator (PI))
Co-Investigator(s)
Professor Li Xuechen
(Co-Investigator)
Dr Kao Richard Yi Tsun
(Co-Investigator)
Dr Sze Kong Hung
(Co-Investigator)
Professor Hao Quan
(Co-Investigator)
Duration
24
Start Date
2020-04-01
Amount
1349656
Conference Title
Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR
Presentation Title
Keywords
chemical genetics, MRSA, SaeR, Staphylococcus aureus, Two-component system, Virulence factor
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
19180692
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
To investigate the mechanism of HR3744 inhibiting SaeR, and evaluate the efficacy in vivo 1. To evaluate the anti-virulence property of HR3744 against clinical strains 2. To identify whether the molecular target of HR3744 is SaeR 3. To investigate the mechanism of specific inhibition by HR3744 against SaeR 4. To determine the in-vivo efficacy of HR3744 against MRSA in virus and bacterial co-infection and other animal models