Deciphering protective factors for intervertebral disc degeneration for mechanistic insights and intervention potentials

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Grant Data
Project Title
Deciphering protective factors for intervertebral disc degeneration for mechanistic insights and intervention potentials
Principal Investigator
Professor Chan, Danny   (Principal Investigator (PI))
Co-Investigator(s)
Dr Ho Joshua Wing Kei   (Co-Investigator)
Dr Song You-qiang   (Co-Investigator)
Duration
48
Start Date
2020-01-01
Amount
1029233
Conference Title
Deciphering protective factors for intervertebral disc degeneration for mechanistic insights and intervention potentials
Keywords
Disc degeneration, human genetics, mouse genetics, protective factors, Spine
Discipline
GeneticsOrthopaedics/Traumatology
Panel
Biology and Medicine (M)
HKU Project Code
17126319
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
On-going
Objectives
1) To perform a genetic linkage analysis to discover protective loci against intervertebral disc degeneration in mouse intervertebral disc; 2) To assess cellular and molecular changes in relation to the protective loci; 3) To study the relevance of the protective loci in human cohorts with ""good IVD/super-normal"" individuals