Inflammation induced cell dedifferentiation program in vertebral joint degeneration

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Grant Data
Project Title
Inflammation induced cell dedifferentiation program in vertebral joint degeneration
Principal Investigator
Dr Leung, Victor Yu Leong   (Principal Investigator (PI))
Co-Investigator(s)
Professor Cheung Jason Pui Yin   (Co-Investigator)
Professor Ho Joshua Wing Kei   (Co-Investigator)
Duration
36
Start Date
2020-01-01
Completion Date
2022-12-31
Amount
919972
Conference Title
Inflammation induced cell dedifferentiation program in vertebral joint degeneration
Keywords
de-differentiation, Inflammation, Interleukin 1, Intervertebral Disc, single cell transcriptomics
Discipline
Cell BiologyRheumatology
Panel
Biology and Medicine (M)
HKU Project Code
17121619
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To consolidate the temporal and dosage effect of IL-1 on human NP cell state 2 To construct an IL-1 induced cell fate hierarchy using scRNA-seq analysis 3 To validate the hierarchy in clinical samples and induced IVD degeneration model