The role of RPS6KA3 mutation in modulating the cholesterol biosynthesis in hepatocellular carcinoma

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Grant Data
Project Title
The role of RPS6KA3 mutation in modulating the cholesterol biosynthesis in hepatocellular carcinoma
Principal Investigator
Professor Ho, Daniel Wai Hung   (Principal Investigator (PI))
Co-Investigator(s)
Professor Ng Irene Oi Lin   (Co-Investigator)
Dr Chan Lo Kong   (Co-Investigator)
Duration
42
Start Date
2019-11-01
Amount
1106719
Conference Title
The role of RPS6KA3 mutation in modulating the cholesterol biosynthesis in hepatocellular carcinoma
Keywords
Cholesterol biosynthesis, Exome Sequencing, HBV-associated HCC, RPS6KA3, RSK2
Discipline
CancerCell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17117019
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To examine the molecular mechanism whereby RSK2 mutation regulates MAPK signaling in HCC 2 To examine the significance of RSK2 mutation in modulating the cholesterol biosynthesis in HCC 3 To examine the potential role of RSK2 mutation in supporting cancer stemness in HCC