Hormonal regulation of decidual glycodelin-A glycosylation and its implication in the pathogenesis of early-onset preeclampsia

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Grant Data
Project Title
Hormonal regulation of decidual glycodelin-A glycosylation and its implication in the pathogenesis of early-onset preeclampsia
Principal Investigator
Professor Chiu, Chi Ngong   (Principal Investigator (PI))
Co-Investigator(s)
Professor Burton Graham   (Co-Investigator)
Professor Ng Ernest Hung Yu   (Co-Investigator)
Dr Lee Cheuk Lun   (Co-Investigator)
Duration
36
Start Date
2020-01-01
Completion Date
2022-12-31
Amount
1113869
Conference Title
Hormonal regulation of decidual glycodelin-A glycosylation and its implication in the pathogenesis of early-onset preeclampsia
Keywords
decidual natural killer cell, Glycodelin, Preeclampsia, Pregnancy, Trophoblast
Discipline
ReproductionPhysiology
Panel
Biology and Medicine (M)
HKU Project Code
17115619
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To confirm the glycosylation heterogeneity of GdA derived from endometrium of different menstrual phases and early gestation 2 To study the role and mechanism of glycosylation in regulating the vascular remodeling activities of GdA 3 To determine the expression and glycosylation of GdA in pregnancy complicated by PE