Myocardial Tissue Engineering with Cells Derived From Human-Induced Pluripotent Stem Cells and a Native Decellularized Placenta Scaffold
Grant Data
Project Title
Myocardial Tissue Engineering with Cells Derived From Human-Induced Pluripotent Stem Cells and a Native Decellularized Placenta Scaffold
Principal Investigator
Dr Liao, Songyan
(Principal Investigator (PI))
Co-Investigator(s)
Professor Tse Hung Fat
(Co-Investigator)
Duration
24
Start Date
2019-10-01
Completion Date
2021-09-30
Amount
1081515
Conference Title
Myocardial Tissue Engineering with Cells Derived From Human-Induced Pluripotent Stem Cells and a Native Decellularized Placenta Scaffold
Presentation Title
Keywords
heart failure, Induced Pluripotent Stem Cells, Myocardial infarction, Placenta, Tissue Engineering
Discipline
Cardiovascular Research,Stem Cell Therapy
Panel
Biology and Medicine (M)
HKU Project Code
17105319
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 1. To determine the biological activity of growth factors and cytokines contained in the decellularized placenta. 2 2. To evaluate cell survival and retention after seeding onto the placenta scaffold, as well as the stiffness and electrophysiological characteristics of this myocardial patch before transplantation. 3 3. To test the hypothesis that cell patch transplantation can enhance the survival and engraftment of hiPSC-CMs and hiPSC-MSCs in a rat model of MI. 4 4. To test the hypothesis that cell patch transplantation can enhance the therapeutic benefits of hiPSC-CMs and hiPSC MSCs without pro-arrhythmia risk in a porcine model of HF post-MI. 5 5. To study the electrical coupling of the graft to the host myocardium and other potential mechanisms of heart function improvement and cell engraftment.