Mechanism of a Δ42PD-1-specific humanized antibody huCH101 in treating HIV/AIDS

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Grant Data
Project Title
Mechanism of a Δ42PD-1-specific humanized antibody huCH101 in treating HIV/AIDS
Principal Investigator
Professor Chen, Zhiwei   (Principal Investigator (PI))
Co-Investigator(s)
Dr Tan Zhiwu   (Co-Investigator)
Duration
36
Start Date
2020-01-01
Completion Date
2022-12-31
Amount
1115993
Conference Title
Mechanism of a Δ42PD-1-specific humanized antibody huCH101 in treating HIV/AIDS
Keywords
AIDS, HIV, inflammation, PD-1, Δ42PD-1
Discipline
MicrobiologyInfection/Parasitology
Panel
Biology and Medicine (M)
HKU Project Code
17104919
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To determine the role of huCH101 and its variants in treating HIV-1-induced immune activation and mucosal damage (year 1-1.5) 2 To determine the efficacy of huCH101 and immune checkpoint inhibitor in treating HIV-1 infection